Author: Robert C. Owens
Publisher: CRC Press
ISBN: 0203996925
Category : Medical
Languages : en
Pages : 684
Book Description
This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi
Antibiotic Optimization
Author: Robert C. Owens
Publisher: CRC Press
ISBN: 0203996925
Category : Medical
Languages : en
Pages : 684
Book Description
This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi
Publisher: CRC Press
ISBN: 0203996925
Category : Medical
Languages : en
Pages : 684
Book Description
This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi
Antibiotic Optimization
Author: Robert C. Owens
Publisher: CRC Press
ISBN: 1135534462
Category : Medical
Languages : en
Pages : 688
Book Description
This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi
Publisher: CRC Press
ISBN: 1135534462
Category : Medical
Languages : en
Pages : 688
Book Description
This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi
The Use of Drugs in Food Animals
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309175771
Category : Medical
Languages : en
Pages : 276
Book Description
The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.
Publisher: National Academies Press
ISBN: 0309175771
Category : Medical
Languages : en
Pages : 276
Book Description
The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.
Treating Infectious Diseases in a Microbial World
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309180686
Category : Medical
Languages : en
Pages : 102
Book Description
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Publisher: National Academies Press
ISBN: 0309180686
Category : Medical
Languages : en
Pages : 102
Book Description
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
Author: Alexander A. Vinks
Publisher: Springer Science & Business Media
ISBN: 0387756132
Category : Medical
Languages : en
Pages : 467
Book Description
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Publisher: Springer Science & Business Media
ISBN: 0387756132
Category : Medical
Languages : en
Pages : 467
Book Description
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
How to Overcome the Antibiotic Crisis
Author: Marc Stadler
Publisher: Springer
ISBN: 3319492845
Category : Medical
Languages : en
Pages : 497
Book Description
This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.
Publisher: Springer
ISBN: 3319492845
Category : Medical
Languages : en
Pages : 497
Book Description
This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.
Optimization of Treatment Protocols to Prevent de Novo Development of Antibiotic Resistance in Pseudomonas Aeruginosa
Author: Yanfang Feng
Publisher:
ISBN:
Category :
Languages : en
Pages : 121
Book Description
The ever-increasing rate of drug resistant bacteria has been one of the most challenging problem worldwide. This thesis studied the following subjects with mostly the clinically leading pathogen, P. aeruginosa, as the model strain: de novo development of antibiotic resistance in patient during the treatment, the influences of the therapy failure of an initial antibiotic treatment on the therapeutic effects of subsequent treatments, the dynamics of mutations during development of resistance by bacteria against the commonly used antibiotics in hospitals, and the optimal ways to administrate drugs in order to cure the infection and at the same time maximally reduce the occurrence of antibiotic resistance.
Publisher:
ISBN:
Category :
Languages : en
Pages : 121
Book Description
The ever-increasing rate of drug resistant bacteria has been one of the most challenging problem worldwide. This thesis studied the following subjects with mostly the clinically leading pathogen, P. aeruginosa, as the model strain: de novo development of antibiotic resistance in patient during the treatment, the influences of the therapy failure of an initial antibiotic treatment on the therapeutic effects of subsequent treatments, the dynamics of mutations during development of resistance by bacteria against the commonly used antibiotics in hospitals, and the optimal ways to administrate drugs in order to cure the infection and at the same time maximally reduce the occurrence of antibiotic resistance.
Improving Antibiotic Therapy in Critically Ill Patients Through Pharmacokinetic Dose Optimization
Author: Caspar Hodiamont
Publisher:
ISBN: 9789464832495
Category :
Languages : en
Pages : 0
Book Description
"Each year, thousands of critically ill patients admitted to Dutch intensive care units suffer from severe bacterial infections. Early and adequate antibiotic treatment significantly lowers the mortality of these infections. The efficacy and safety of antibiotics like gentamicin, vancomycin and ceftazidime depends on the concentrations that are achieved in serum and in infected body tissues. However, it is particularly difficult to achieve adequate antibiotic concentrations in critically ill patients because the pharmacokinetic processes may vary widely, both between these patients and within an individual patient during different stages of the infection. To increase the probability that effective antibiotic concentrations are reached timely in these patients, the use of optimized dosing strategies is recommended. This thesis investigates several of these strategies, ranging from the effect of a higher starting dose for all critically ill patients or for some individuals with specific patient characteristics to the use of continuous infusion or the use of therapeutic drug monitoring."--
Publisher:
ISBN: 9789464832495
Category :
Languages : en
Pages : 0
Book Description
"Each year, thousands of critically ill patients admitted to Dutch intensive care units suffer from severe bacterial infections. Early and adequate antibiotic treatment significantly lowers the mortality of these infections. The efficacy and safety of antibiotics like gentamicin, vancomycin and ceftazidime depends on the concentrations that are achieved in serum and in infected body tissues. However, it is particularly difficult to achieve adequate antibiotic concentrations in critically ill patients because the pharmacokinetic processes may vary widely, both between these patients and within an individual patient during different stages of the infection. To increase the probability that effective antibiotic concentrations are reached timely in these patients, the use of optimized dosing strategies is recommended. This thesis investigates several of these strategies, ranging from the effect of a higher starting dose for all critically ill patients or for some individuals with specific patient characteristics to the use of continuous infusion or the use of therapeutic drug monitoring."--
Pharmacokinetics and Pharmacodynamics
Author: Patricia D. Kroboth
Publisher: Harvey Whitney Books Company
ISBN:
Category : Medical
Languages : en
Pages : 276
Book Description
Publisher: Harvey Whitney Books Company
ISBN:
Category : Medical
Languages : en
Pages : 276
Book Description
Antimicrobial Stewardship
Author: Kerry LaPlante
Publisher: CABI
ISBN: 1780644396
Category : Medical
Languages : en
Pages : 451
Book Description
In an age where antimicrobial resistance amongst pathogens grows more prevalent, particularly in the hospital setting, antimicrobial stewardship is an evidence-based, proven measure in the battle against resistance and infection. This single comprehensive, definitive reference work is written by an international team of acknowledged experts in the field. The authors explore the effective use of coordinated antimicrobial interventions to change prescribing practice and help slow the emergence of antimicrobial resistance, ensuring that antimicrobials remain an effective treatment for infection. Amongst the first of its kind, this book provides infectious disease physicians, administrators, laboratory, pharmacy, nursing and medical staff with practical guidance in setting up antimicrobial stewardship programs in their institutions with the aim of selecting the optimal antimicrobial drug regimen, dose, duration of therapy, and route of administration.
Publisher: CABI
ISBN: 1780644396
Category : Medical
Languages : en
Pages : 451
Book Description
In an age where antimicrobial resistance amongst pathogens grows more prevalent, particularly in the hospital setting, antimicrobial stewardship is an evidence-based, proven measure in the battle against resistance and infection. This single comprehensive, definitive reference work is written by an international team of acknowledged experts in the field. The authors explore the effective use of coordinated antimicrobial interventions to change prescribing practice and help slow the emergence of antimicrobial resistance, ensuring that antimicrobials remain an effective treatment for infection. Amongst the first of its kind, this book provides infectious disease physicians, administrators, laboratory, pharmacy, nursing and medical staff with practical guidance in setting up antimicrobial stewardship programs in their institutions with the aim of selecting the optimal antimicrobial drug regimen, dose, duration of therapy, and route of administration.