2019 Antibacterial agents in clinical development PDF Download

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240000194
Category : Medical
Languages : en
Pages : 48

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Author:
Publisher:
ISBN:
Category : Antibacterial agents
Languages : en
Pages : 45

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"A new WHO report shows a serious lack of new antibiotics under development to combat the growing threat of antimicrobial resistance. The report found very few potential treatment options for those antibiotic-resistant infections identified by WHO as posing the greatest threat to health, including drug-resistant tuberculosis which kills around 250,000 people each year."--

Author:
Publisher: World Health Organization
ISBN: 9240021302
Category : Business & Economics
Languages : en
Pages : 76

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This report is the World Health Organization’s (WHO) fourth annual review of the clinical antibacterial pipeline, and the second review of the preclinical antibacterial pipeline. The WHO’s annual antibacterial pipeline report reviews antibiotics that are in the clinical stages of development as well as those in early development to assess the progress and gaps in relation to urgent threat of drug-resistance.The report evaluates the potential of these antibacterial candidates in development to address the most threatening drug-resistant bacteria as outlined in the WHO Bacterial Priority Pathogens List (WHO PPL). This report covers direct-acting small molecules and biological agents that are in development worldwide. In this fourth edition, the report includes for the first time a comprehensive overview of non-traditional antibacterial medicines. This report is part of the WHO’s efforts in global research and development (R&D) priority setting to contain antimicrobial resistance. All the data contained in this report can be downloaded from the WHO Global Observatory on Health R&D.

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240047654
Category : Business & Economics
Languages : en
Pages : 104

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Author: world health organization
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309030447
Category : Medical
Languages : en
Pages : 393

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Author: Thomas J. Dougherty
Publisher: Springer Science & Business Media
ISBN: 1461414008
Category : Medical
Languages : en
Pages : 1119

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This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309185548
Category : Medical
Languages : en
Pages : 397

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Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.

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Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309180686
Category : Medical
Languages : en
Pages : 102

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Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.