Anthracycline Antibiotics in Cancer Therapy PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Anthracycline Antibiotics in Cancer Therapy PDF full book. Access full book title Anthracycline Antibiotics in Cancer Therapy by Franco M. Muggia. Download full books in PDF and EPUB format.
Author: Franco M. Muggia Publisher: Springer Science & Business Media ISBN: 9400976305 Category : Medical Languages : en Pages : 580
Book Description
F. M. MUGGIA When faced with the inadequacies of current cancer treatment, we prefer to look at what the future may hold. Quite often, we take for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics represent much of the present and future of cancer treatment, their actual use c stretches back barely two decades to the pioneering efforts of Aurelio Di Marco, who characterized the antitumor properties of daunomycin and adriamycin. * The clinical application of these two compounds heralded a decade of excitement among oncologists dealing with pediatric tumors, breast cancer, leukemias, and lymphomas, and opened new hope for patients afflicted with sar comas and a variety of other tumors that had been deemed - sistant to chemotherapy. These successes were tempered with the realization that the antitumor effect of anthracyclines could be achieved at times only at the very high price of risking cardiac decompensation and, almost invariably, with the occurrence of alopecia and other acute toxicities. This record of past achievements and problems has slowly given way to a present increasingly illuminated by our ability to modify the distressing toxicities of these agents. Detailed clinical studies supplemented by ingenious laboratory models have gradually elucidated mechanisms and risk factors im plicated in the cardiomyopathy.
Author: Franco M. Muggia Publisher: Springer Science & Business Media ISBN: 9400976305 Category : Medical Languages : en Pages : 580
Book Description
F. M. MUGGIA When faced with the inadequacies of current cancer treatment, we prefer to look at what the future may hold. Quite often, we take for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics represent much of the present and future of cancer treatment, their actual use c stretches back barely two decades to the pioneering efforts of Aurelio Di Marco, who characterized the antitumor properties of daunomycin and adriamycin. * The clinical application of these two compounds heralded a decade of excitement among oncologists dealing with pediatric tumors, breast cancer, leukemias, and lymphomas, and opened new hope for patients afflicted with sar comas and a variety of other tumors that had been deemed - sistant to chemotherapy. These successes were tempered with the realization that the antitumor effect of anthracyclines could be achieved at times only at the very high price of risking cardiac decompensation and, almost invariably, with the occurrence of alopecia and other acute toxicities. This record of past achievements and problems has slowly given way to a present increasingly illuminated by our ability to modify the distressing toxicities of these agents. Detailed clinical studies supplemented by ingenious laboratory models have gradually elucidated mechanisms and risk factors im plicated in the cardiomyopathy.
Author: Carmen Avendaño Publisher: Elsevier ISBN: 0444626670 Category : Science Languages : en Pages : 767
Book Description
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
Author: Boris Minev Publisher: Springer Science & Business Media ISBN: 904819704X Category : Medical Languages : en Pages : 521
Book Description
This book represents a comprehensive description and evaluation of the most up-to-date approaches to cancer management. Each chapter, prepared by leading basic researchers and clinicians, provides an in depth description of a specific method for cancer management. The chemotherapy section of the book is updated to include the newest drugs as well as those currently in development. Organized by drug class, this section provides the latest information on most drugs, including their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The biological therapy section of the book provides expanded coverage of the currently used cytokines, vaccines, and cell based therapies of cancer. Full consideration is also given to other modern treatment approaches, such as tyrosine kinase inhibitors, inhibitors of tumor angiogenesis, and the transcatheter management of cancer. Current advances in hyperthermia in cancer treatment, hematologic and nutritional support, bone marrow transplantation, pain management and care of the terminally ill patients with cancer are also presented. In summary, this book provides a comprehensive coverage of the current knowledge on the most innovative, systematic and multidisciplinary approaches to the treatment of patients with cancer.
Author: S.K. Carter Publisher: Springer Science & Business Media ISBN: 3642812198 Category : Medical Languages : en Pages : 315
Book Description
The scientific collaboration between the United States and Japan in the field of cancer goes back many years. In this successful international collaboration cancer chemotherapy has been one of the most productive areas. Pioneers such as YOSHIDA, UMEZAWA, SHEAR, and GOLDIN established firm links of mutual trust and respect in the period after the Second Great War. Japanese drugs, such as mitomycin C and bleomycin have become mainstays of clinical oncology in the U. S. and throughout the world. Many drugs developed in the U. S. have become established in Japanese cancer therapy. Within the cancer chemotherapy field the antitumor antibiotics rank as one of the most important groups. In the U . S. -J apanese collaboration this group of drugs has taken the paramount role. The Japanese, under the leadership of U mezawa, are considered to be among the most innovative and productive in this area which has also had great emphasis in the United States as part of the National Cancer Institute's drug development program and in the pharmaceutical industry. This extended collaboration in general oncology, and chemotherapy in particular, has received increased impetus by and support from the official U . S. -J apan Joint Agreement on cancer research, which was established in 1974 between the National Cancer Institute and the Japanese Society for the Promotion of Science. One of the subsections of this agreement is cancer therapy with emphasis on chemotherapy.
Author: American Chemical Society. Meeting Publisher: ISBN: Category : Medical Languages : en Pages : 352
Book Description
Developed from a symposium at the 205th National Meeting of the ACS in Denver, March 1993, held to bring together researchers who are involved in the direct design and synthesis of new drugs with researchers who are investigating biochemical processes and mechanisms of action. The volume covers research relevant to the development of novel anthracyclines, such as the synthesis of promising new analogs, studies of mechanisms of action, and new approaches to improving properties for this class of compounds by using different drug- delivery and tumor-targeting systems. Annotation copyright by Book News, Inc., Portland, OR
Author: Patrizio Lancellotti Publisher: Academic Press ISBN: 0128026472 Category : Medical Languages : en Pages : 483
Book Description
Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post-treatment issues among survivors of adult cancer. Early detection of the patients prone to developing cardiotoxicity, taking in to account the type of treatment, history and other risk factors, is essential in the fight to decrease cardiotoxic mortality. This illustrated reference describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. - Provides algorithms essential for the use of imaging, and biomarkers for the screening and monitoring of patients - Written by world-leading experts in the field of cardiotoxicity - Includes high-quality images, case studies, and test questions - Describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment
Author: Ajay Vora Publisher: Springer ISBN: 3319397087 Category : Medical Languages : en Pages : 345
Book Description
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Author: John W. Corcoran Publisher: Springer ISBN: 9783540101864 Category : Medical Languages : en Pages : 382
Book Description
The Series on Antibiotics produced by Springer-Verlag began more than a decade ago with the nearly simultaneous appearance of two volumes, one dealing with the mode of action of antibiotics and the other concerning the biosynthesis of them. The standards set by the original Editors were high, and these books have proved useful to many. The rapid advances in our knowl edge of the mode of action of antibiotics and other antitumor agents has stimu lated two further works in the same series (Volume III, 1975; and Volumes Vj1 and Vj2, 1979). For some time it had appeared to Dr. Konrad Springer that the time might' be ripe' for bringing the subject of the biosynthesis of antibiotics up-to-date. This Editor agreed to survey the literature and discuss this possibility with his colleagues who are active in research on antibiotics. In spite of the appearance of numerous review articles, both of a highly special ized and general nature, on the biosynthesis of antibiotics, it was agreed generally that it would be extremely useful to add a new volume on biosynthesis to the Series. Such a work should focus on collecting a group of contributions dealing with those antibiotics whose biosynthesis is understood in much greater detail now than it was in the middle 1960's. Since Volume II on biosynthesis continues to be available, this addition to the series has not dealt with each and every antibiotic whose biosynthesis was studied long ago.
Author: Franco M. Muggia
Author: Franco M. Muggia
Author: Carmen Avendaño
Author: Boris Minev
Author: S.K. Carter
Author: American Chemical Society. Meeting
Author: Patrizio Lancellotti
Author: Hassan Saad El Khadem
Author: Ajay Vora
Author: Karsten Krohn
Author: John W. Corcoran