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Author: Matthias Kirsch Publisher: Springer Science & Business Media ISBN: 1441988718 Category : Medical Languages : en Pages : 376
Book Description
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Author: Matthias Kirsch Publisher: Springer Science & Business Media ISBN: 1441988718 Category : Medical Languages : en Pages : 376
Book Description
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Author: Domenico Ribatti Publisher: Academic Press ISBN: 0128194944 Category : Science Languages : en Pages : 198
Book Description
Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
Author: Prashant Kesharwani Publisher: Academic Press ISBN: 0128122498 Category : Medical Languages : en Pages : 480
Book Description
Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. - Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness - Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine - Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors
Author: Thomas H. Adair Publisher: Morgan & Claypool Publishers ISBN: 1615043306 Category : Medical Languages : en Pages : 85
Book Description
Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life's most threatening medical conditions. The lives of at least 1 billion people worldwide could be improved with angiogenic therapy, according to the Angiogenesis Foundation. In this little book, we provide a simple approach to understand the essential elements of the angiogenic process, we critique the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and we provide an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body. All tissues of the body require a continuous supply of oxygen to burn metabolic substrates that are needed for energy. Oxygen is conducted to these tissues by blood capillaries: more capillaries can improve tissue oxygenation and thus enhance energy production; fewer capillaries can lead to hypoxia and even anoxia in the tissues. This means that angiogenic therapies designed to control the growth and regression of blood capillaries can be used to improve the survival of poorly perfused tissues that are essential to the body (heart, brain, skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors). Table of Contents: Overview of Angiogenesis / Angiogenesis Assays / Regulation: Metabolic Factors / Regulation: Mechanical Factors / Glossary / References / Author Biographies
Author: Carolyn A. Staton Publisher: John Wiley & Sons ISBN: 047002934X Category : Medical Languages : en Pages : 410
Book Description
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author: Paul Kleihues Publisher: ISBN: Category : Medical Languages : en Pages : 326
Book Description
The second edition of this concise reference book was prepared by 106 authors from 21 countries and covers the neuro-oncological literature until January 2000. Diagnostic criteria, pathological features and associated genetic alterations are described in a strictly disease-oriented manner. Sections on more than 70 neoplasms and their variants include ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics and predictive factors. New disease entities include the chordoid glioma of the third ventricle and the cerebellar liponeurocytoma. Inherited tumor syndromes involving the nervous system are dealt with in a separate chapter, combining diagnostic criteria, pathology and genetics.
Author: Damir Janigro Publisher: Springer Science & Business Media ISBN: 1597450219 Category : Medical Languages : en Pages : 555
Book Description
Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
Author: A. Gregory Sorensen Publisher: Thieme ISBN: 9780865779259 Category : Medical Languages : en Pages : 174
Book Description
This book will familiarize the reader with the basic principles of perfusion MR imaging. Relevant technical aspects, contrast agents, and the postprocessing of images are presented, and imaging protocols are provided. Dedicated software for personal use on the postprocessing of images is provided on a CD-ROM containing hundreds of images and movie clips that demonstrate all concepts. In addition to the technical details of acquisition and postprocessing, numerous examples of the application of these tools in the clinical setting are also shown. In particular, the book includes a discussion of the role of perfusion MRI in the current evaluation of cerebrovascular disease, including an integrative approach using diffusion in conjunction with perfusion imaging. This text covers: all relevant technical aspects of perfusion MR imaging imaging protocols application of these tools in a clinical setting integration of diffusion imaging with perfusion imaging for enhanced diagnostic capabilities Also addressed are the role of perfusion MRI in the assessment of cerebral neoplasia, challenges and opportunities for treatment that tumors present, and the particular strengths of perfusion MRI, such as its relatively high resolution and possible microvascular specificity. For both newcomers and experienced practitioners, this is a nuts-and-bolts description of an important new technique.
Author: Herbert B. Newton Publisher: Academic Press ISBN: 0128121017 Category : Medical Languages : en Pages : 852
Book Description
Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. - Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors - Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors - Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods - Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors
Author: Swapan K. Ray Publisher: Springer Science & Business Media ISBN: 1441904107 Category : Medical Languages : en Pages : 427
Book Description
Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.
Author: Matthias Kirsch
Author: Matthias Kirsch
Author: Domenico Ribatti
Author: Prashant Kesharwani
Author: Thomas H. Adair
Author: Carolyn A. Staton
Author: Paul Kleihues
Author: Damir Janigro
Author: A. Gregory Sorensen
Author: Herbert B. Newton
Author: Swapan K. Ray