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Author: Zhou Wang Publisher: Springer Science & Business Media ISBN: 1461461820 Category : Medical Languages : en Pages : 347
Book Description
Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.
Author: Zhou Wang Publisher: Springer Science & Business Media ISBN: 1461461820 Category : Medical Languages : en Pages : 347
Book Description
Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.
Author: Donald Tindall Publisher: Springer Science & Business Media ISBN: 0387691790 Category : Medical Languages : en Pages : 782
Book Description
Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
Author: Donald J. Tindall Publisher: Springer ISBN: 9780387691770 Category : Medical Languages : en Pages : 826
Book Description
Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
Author: Feng Jiang Publisher: ISBN: Category : Languages : en Pages :
Book Description
Androgens are required for the structural and functional integrity of the prostate. Androgen action is intimately involved in the pathogenesis of two major prostate diseases, benign prostatic hyperplasia (BPH) and prostate carcinoma (CaP). Androgens regulate gene expression in the prostate through the androgen receptor (AR), a ligand-dependent transcription factor. To understand the molecular and cellular mechanisms of androgen action in the prostate, I used both cDNA subtractive hybridizations and microarray to comprehensively identify genes regulated by androgens using the rat ventral prostate model. Twenty-two genes up-regulated by androgens were isolated from my subtraction studies. From my microarray study, 162 and 143 genes were found to be up-regulated and down-regulated by androgens, respectively. Identification of these genes suggests that the following pathways are activated by androgens in the prostate---metabolism, protein synthesis, protein chaperoning and trafficking, secretions, cell cycle and apoptosis, and structural and extracellular proteins. I have characterized four androgen-responsive genes: FPPS, PLZF, GADD45gamma, and U19. FPPS is abundantly expressed and regulated by androgens in the rat prostatic epithelial cells. Both PLZF and GADD45gamma are found to be growth-suppressive to prostate cancer cells, suggesting that androgens might activate a signaling pathway to counteract the androgen-induced cell proliferation pathway. U19, a novel androgen-responsive apoptosis inducer, is also growth-suppressive to prostate cancer. Therefore, U19 was chosen for further mechanistic study. I identified FBI as a protein partner for U19. I determined that FB1 also interacts with EAF1, PML and ELL, and FB1 inhibits the transcriptional activity of U19. In conclusion, my thesis established a foundation for future mechanistic study of androgen action and provided new insights into the roles played by androgens in the prostate.
Author: D.S. Coffey Publisher: Springer Science & Business Media ISBN: 1461537045 Category : Medical Languages : en Pages : 379
Book Description
These proceedings of the 5th Prouts Neck Meeting on Prostate Cancer, held in October, 1989, highlight the many advances in the understanding of prostatic growth and function at the cellular and molecular levels which have been registered since the first Prouts Neck Meeting in 1985, a meeting which also focused on the then current concepts and basic approaches to understanding prostate cancer. Inter vening Prouts Neck Meetings in 1986, 1987 and 1988 were devoted to treatment, image cytometry and clinical markers. As before, the Prouts Neck tradition of bringing together an international, multidiscipli nary group of experts for 3 days to exchange ideas and new data, in the relaxed atmosphere of an old iun on the scenic Maine coast, proved to be an ideal combination for a highly successful conference. Accordingly, the Organ System Program of the National Cancer Institute plans to use the Prouts Neck model for future conferences on other solid tumors (bladder in 1990 and kidney in 1991) and will return to the prostate in 1992. A new dimension was added to the current program through the inclusion of a poster session to recognize the research of pre-and postdoctoral investigators. The posters were judged by Drs. Collette Freeman, Frank French, Shutsung Liao, Robert Matusik and Henry Sun. The three winners, in alphabeti cal order, were John Fabian, Robert Getzenberg and Ming Fong-Lin.
Author: Publisher: ISBN: Category : Languages : en Pages : 11
Book Description
We hypothesize that ART-27 affects AR-dependent differentiation of prostate epithelial cells by regulating a subset of AR responsive genes important to prostate growth suppression and differentiation. We further hypothesize that alterations in the level of ART-27 modulates AR activity, which, in turn, affects AR-dependent cell growth regulation in vivo. Our aims are to identify ART-27-dependent AR-target genes involved in growth suppression and differentiation and to elucidate the mechanism of regulation of ART-27 expression in prostate cancer. Our approach is to ablate ART-27 protein using siRNA technology followed by gene expression array. Our preliminary findings indicate that loss of ART-27 may result in enhanced expression of genes that are often over-expressed in prostate cancer such as PSA, FKBP5, SOR, KRT18, and CDKN3. Loss of ART-27 also shows enhanced expression of at least one positive regulator of tumor growth, CDKN3.
Author: Shane W. Oram Publisher: ISBN: Category : Languages : en Pages :
Book Description
In the United States, prostate cancer is the most diagnosed form of cancer and the second leading cause of cancer related death in men. Androgens are the major growth factor for the prostate and have long been associated with prostate cancer. Androgens also act as the major differentiation factor of prostate epithelial cells and even have a role in apoptosis of these cells. Androgens exert their effects on the prostate by regulating the expression of various androgen-response genes. These genes are involved in a variety of cellular processes and are thought to regulate the growth, differentiation, and apoptosis of the prostate. Recent studies have worked on identifying the androgen-response genes in the prostate, many of which are known genes, such as PSA, Calreticulin, etc. However, some encode novel gene products in which there is no known function. This study was undertaken to better understand androgen action in the prostate by investigating the regulation and function of two novel androgen-response genes. These two genes, S100RVP and ALP1, were studied in the rat ventral prostate, the Dunning rat prostate cancer cell lines, and also in the human prostate cancer cell lines (LNCaP, PC3, and DU145). S100RVP is a new member of the S100 calcium-binding protein family. It is a delayed androgen-response gene that is involved in the calcium homeostasis of prostate epithelial cells. ALP1 is the mammalian orthologue to a bacterial protein termed ARD/ARD'. ARD proteins are enzymes involved in the Methionine salvage pathway, which is required for growth, polyamine synthesis, and is the primary source of Methyl donor groups. ALP1 is a primary androgen-response gene that is down-regulated in high Gleason grade prostate tumors, down-regulated in the prostate cancer cell lines and whose expression induces apoptosis in these same cells. ALP1 appears to be a novel mammalian ARD-like protein which possesses tumor suppressor like properties.
Author: Emmanuel S. Antonarakis Publisher: MDPI ISBN: 3038427403 Category : Medical Languages : en Pages : 245
Book Description
This book is a printed edition of the Special Issue "AR Signaling in Human Malignancies: Prostate Cancer and Beyond" that was published in Cancers
Author: Jay Young Gillenwater Publisher: Lippincott Williams & Wilkins ISBN: 9780781732208 Category : Medical Languages : en Pages : 1144
Book Description
The updated edition of this classic three-volume work is a comprehensive reference on all surgical and medical aspects of urology. The first two volumes cover adult urology; the third volume focuses on pediatric urology. Includes expanded coverage of prostate disease, male sexual dysfunction, spinal cord injuries, and more. The CD-ROM provides quick access to the full text of the book, plus video clips of surgical procedures. 2,704.
Author: Zhou Wang
Author: Zhou Wang
Author: Donald Tindall
Author: Donald J. Tindall
Author: Feng Jiang
Author: D.S. Coffey
Author: 
Author: Manfred Wirth
Author: Shane W. Oram
Author: Emmanuel S. Antonarakis
Author: Jay Young Gillenwater