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Author: Q. Alan Xu Publisher: John Wiley & Sons ISBN: 0470922796 Category : Science Languages : en Pages : 913
Book Description
This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.
Author: Q. Alan Xu Publisher: John Wiley & Sons ISBN: 0470922796 Category : Science Languages : en Pages : 913
Book Description
This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.
Author: Steven H.Y. Wong Publisher: CRC Press ISBN: 1351364286 Category : Medical Languages : en Pages : 367
Book Description
Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.
Author: Seth Kwabena Amponsah Publisher: Springer Nature ISBN: 3031123980 Category : Medical Languages : en Pages : 384
Book Description
This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges
Author: Amitava Dasgupta Publisher: Springer Science & Business Media ISBN: 1597450316 Category : Medical Languages : en Pages : 441
Book Description
Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.
Author: Steven H.Y. Wong Publisher: Routledge ISBN: 135140847X Category : Medical Languages : en Pages : 521
Book Description
This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.
Author: Randall C. Baselt Publisher: CRC Press ISBN: Category : Medical Languages : en Pages : 354
Book Description
Procedures to determine overdosage or poisoning include: colorimetry, visible and ultraviolet spectrophotometry, mass and atomic absorption spectrometry, flame photometry, ion-specific potentiometry, graphite furnace atomic absorption, liquid chromatography and thin layer chromatography. Gas chromatography procedures include flame ionization, electron capture, nitrogen specific, and thermal conductivity.
Author: Georg Hempel Publisher: Elsevier ISBN: 0080530540 Category : Science Languages : en Pages : 379
Book Description
Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field
Author: Georg Hempel Publisher: Elsevier ISBN: 0444640673 Category : Science Languages : en Pages : 380
Book Description
Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories
Author: A. Poklis Publisher: ISBN: Category : Body fluids Languages : en Pages : 1
Book Description
This is the second edition of a popular laboratory procedures manual first published in 1980. The volume retains the same format as the original work. Drugs or classes of drugs commonly analyzed for in therapeutic monitoring or clinical toxicology are indexed in alpha-betical order with one or more specific procedures for their analysis in blood, plasma, serum, and/or urine presented. Each procedure includes: the principle of the method, necessary reagents and their preparation, instrumental conditions, extraction protocol, calculation of results, performance characteristics, and possible interferences with the assay. The directions are well written, clear, concise, and easy to follow. Should the analyst wish to inquire further, at least one reference is presented for each procedure. One hundred seventy-four procedures for the analysis of one hundred and one drugs are presented. Unfortunately, only IS of these are new additions to the 1980 first edition. The remaining 159 procedures are exactly as previously published reflecting 1970s technologies (for example, packed gas chromatographic [GC] columns, flame ionization detectors [FID]).
Author: Q. Alan Xu
Author: Q. Alan Xu
Author: Steven H.Y. Wong
Author: Seth Kwabena Amponsah
Author: Amitava Dasgupta
Author: Steven H.Y. Wong
Author: Randall C. Baselt
Author: Georg Hempel
Author: Georg Hempel
Author: A. Poklis
Author: Baselt RC.