Author: Jeffrey Morse HollowayPublisher:
ISBN:
Category :
Languages : en
Pages : 390
Book Description
Analysis of the Molecular Basis of Transcriptional Regulation by Thyroid Hormone and Estrogen Receptors
Author: Jeffrey Morse HollowayPublisher:
ISBN:
Category :
Languages : en
Pages : 390
Book Description
Molecular Basis of Thyroid Hormone Action
Author: Jack OppenheimerPublisher: Elsevier
ISBN: 0323147453
Category : Science
Languages : en
Pages : 515
Book Description
Molecular Basis of Thyroid Hormone Action focuses on the actions of thyroid hormones in eukaryotic cells. This book discusses the profound effects of thyroid hormones on the growth, development, and metabolism of practically all tissues of higher organisms. Organized into 15 chapters, this volume starts with an overview of the kinetic interrelationships of hormone bound to specific receptors and hormone associated with other tissue and plasma pools in living animals. This book then discusses the thyroid hormone receptor, a chromatin-associated protein that appears to mediate the actions of the thyroid hormones in mammalian cells. Other chapters consider the localization of the receptors in chromatin. This book further discusses how thyroid hormones stimulate the accumulation of specific mRNA molecules in cell culture as well as in tissues in vivo. This book is intended for readers who are interested in cell and molecular biology. Endocrinologists will also find this book extremely useful.
Analysis of the Molecular Mechanisms of Isoform-specific Transcriptional Regulation by Thyroid Hormone Receptors
Author: Zhihong YangThyroid Hormone Regulation of Gene Expression
Author: G.R. WilliamsPublisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 160
Book Description
This book covers the historical perspective and physiological background of the role of thyroid hormones. In both specific target tissues and during development, it provides clinical perspectives and physiological and developmental implications of the interactions between retinoid and vitamin D3 signalling pathways.
Molecular Mechanisms of Thyroid Hormone and Retinoid Receptor Transcriptional Regulation
Author: Anders Michael NäärMolecular Analysis of Thyroid Hormone Receptors and Retinoic Acid Receptors
Author: Theresa Qui PhanPublisher:
ISBN: 9781109662948
Category :
Languages : en
Pages :
Book Description
Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) are members of the nuclear hormone receptor family. These ligand-regulated transcription factors bind to specific DNA sequences, called response elements, as homodimers or heterodimers with retinoid-X receptor (RXR) and regulate specific target genes. In the absence of hormone, TR and RAR repress transcription by recruiting corepressor complexes. In the presence of hormone, a coactivator complex is recruited and results in transcriptional activation. TRs and RARs are highly structurally conserved and possess very similar DNA binding domains. Despite these similarities, these receptors bind to different response elements in the genome, regulate different target genes, and control distinct physiological processes. The work presented in this dissertation identifies the DNA recognition properties of TR and RAR that account for these receptors' response element binding specificity and, subsequently, their distinct physiological responses. While response elements based on the consensus half-site are high affinity binding sites for TR and RAR, they show poor specificity. In contrast, the variations in half-site sequence, flanking sequences, and spacing found in natural TR and RAR target genes generate response elements that are bound in vitro and transcriptionally activated in vivo in a receptor-specific manner. Not all DNA sequences that bind TR or RAR efficiently in vitro are able to confer transcriptional regulation in vivo; we provide evidence that auxiliary proteins in cells may destabilize the binding of nuclear receptors to improperly spaced response elements to generate an additional layer of receptor-specific target gene recognition.
Regulatory Mechanisms in Transcriptional Signaling
Author: Publisher: Academic Press
ISBN: 0080911986
Category : Science
Languages : en
Pages : 413
Book Description
Regulatory Mechanisms in Transcriptional Signaling, volume of Progress in Molecular Biology and Translational Science, includes in-depth discussion on roles of Chromatin remodeling proteins in nuclear receptor signaling, and the ANCCA regulator in cancer. This important resource, edited by Dr. Debabrata (Debu) Chakravarti, offers research on the progesterone receptor action in leiomyoma and endometrial cancer and emerging roles of the ubiquitin protein system in nuclear hormone receptor signaling to provide the reader with expert discussions of up-to-date research.
Thyroid Hormone Receptors
Author: Aria BaniahmadPublisher: Springer Science & Business Media
ISBN: 1592591744
Category : Medical
Languages : en
Pages : 232
Book Description
A panel of outstanding investigators surveys and explains the major cutting-edge methods used in thryroid receptor (TR) research and explains their practical experimental details. Described in step-by-step detail to ensure robust experimental results, the techniques presented cover a wide variety of key areas, including TR in development and knockout (mouse and Xenopus), transcriptional regulation by TRs in both cell-free systems and in living cells, and TR mutant analysis of patients. Additional methods provide powerful tools for the isolation of TR-regulated protein complexes, for studying the oncogene v-Erba in blood cell differentiation, and for target gene analysis in the brain. Microarray chip methods are also presented for analyzing the organs of transgenic mice to identify target genes in the liver.
Elucidation of the Molecular Basis of Syndrome of Resistance to Thyroid Hormone (RTH)
Author: Sunnie Myeung-Sun YohPublisher:
ISBN:
Category :
Languages : en
Pages : 334
Book Description
Glucocorticoid Signaling
Author: Jen-Chywan WangPublisher: Springer
ISBN: 1493928953
Category : Science
Languages : en
Pages : 387
Book Description
This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.