Analysis of Chemical Warfare Agents: General Overview, LC-MS Review, In-House LC-ESI-MS Methods and Open Literature Bibliography PDF Download
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Author: Publisher: ISBN: Category : Languages : en Pages : 90
Book Description
Ratification of the Chemical Weapons Convention by more than 165 States Parties has reduced the risk of chemical warfare agent use, but there still remains a concern that other parties may make use of these weapons against civilian or military targets. Concerns within the defense and homeland security communities over possible terrorist use as well as the requirements for a verifiable Chemical Weapons Convention have driven the development of analytical methods such as liquid chromatography-mass spectrometry (LC-MS) for the detection and identification of chemical warfare agents. This paper provides a general overview of chemical warfare agents and analytical methods for their analysis, a focused review of LC-MS applications, a summary of in-house LC-MS methods developed at DRDC Suffield, and a comprehensive bibliography of analytical open literature papers dealing with chemical warfare agent detection and identification. The review sections provide the homeland security and defense communities with an overview of chemical warfare agents and analytical methods for their determination. Researchers interested in developing new methods for chemical warfare agents may use the reviewed material to quickly ascertain the state of development of analytical methods, in particular LC-MS methods, for chemical warfare agents. The reviewed materials will be used for reference purposes during the development of high field asymmetric waveform ion mobility spectrometry (FAIMS) mass spectrometry, a new analytical technique with the potential to rapidly separate and identify chemical warfare agents. The report concludes with 67 references. Appendix A is a 454-item bibliography of open literature analytical methods for the detection and identification of chemical warfare agents, their degradation products, and related compounds. Paper copies of each paper are held at DRDC Suffield and this comprehensive database of methods continues to be updated regularly using Procite software.
Author: Publisher: ISBN: Category : Languages : en Pages : 90
Book Description
Ratification of the Chemical Weapons Convention by more than 165 States Parties has reduced the risk of chemical warfare agent use, but there still remains a concern that other parties may make use of these weapons against civilian or military targets. Concerns within the defense and homeland security communities over possible terrorist use as well as the requirements for a verifiable Chemical Weapons Convention have driven the development of analytical methods such as liquid chromatography-mass spectrometry (LC-MS) for the detection and identification of chemical warfare agents. This paper provides a general overview of chemical warfare agents and analytical methods for their analysis, a focused review of LC-MS applications, a summary of in-house LC-MS methods developed at DRDC Suffield, and a comprehensive bibliography of analytical open literature papers dealing with chemical warfare agent detection and identification. The review sections provide the homeland security and defense communities with an overview of chemical warfare agents and analytical methods for their determination. Researchers interested in developing new methods for chemical warfare agents may use the reviewed material to quickly ascertain the state of development of analytical methods, in particular LC-MS methods, for chemical warfare agents. The reviewed materials will be used for reference purposes during the development of high field asymmetric waveform ion mobility spectrometry (FAIMS) mass spectrometry, a new analytical technique with the potential to rapidly separate and identify chemical warfare agents. The report concludes with 67 references. Appendix A is a 454-item bibliography of open literature analytical methods for the detection and identification of chemical warfare agents, their degradation products, and related compounds. Paper copies of each paper are held at DRDC Suffield and this comprehensive database of methods continues to be updated regularly using Procite software.
Author: Markku Mesilaakso Publisher: John Wiley & Sons ISBN: 0470854251 Category : Science Languages : en Pages : 476
Book Description
Describes the procedures for collection of samples, sample preparation, and analysis of CWC-related chemicals. It deals with analytical procedures that can be followed in well-equipped off-site laboratories (designated laboratories), as well as the on-site analytical procedures that the OPCW inspectors use in sample collection and preliminary analysis of the samples in field conditions. A one-of-a-kind, highly topical handbook for every expert in the chemical weapons field Outlines the methods for analysing chemical weapons both on and off site Authored by international experts in the field from top laboratories in both government and academic institutions
Author: Jack Cazes Publisher: CRC Press ISBN: 1439870675 Category : Science Languages : en Pages : 2968
Book Description
Thoroughly revised and expanded, this third edition offers illustrative tables and figures to clarify technical points in the articles and provides a valuable, reader-friendly reference for all those who employ chromatographic methods for analysis of complex mixtures of substances. An authoritative source of information, this introductory guide to specific chromatographic techniques and theory discusses the relevant science and technology, offering key references for analyzing specific chemicals and applications in industry and focusing on emerging technologies and uses.
Author: M. Heyl Publisher: Springer Science & Business Media ISBN: 940115600X Category : Science Languages : en Pages : 351
Book Description
One of the major problems associated with the disposal of chemical weapons is that the agents have degraded over time, some quite seriously. Detecting and identifying the products of this decomposition are necessary prerequisites to the safe, complete and environmentally benign destruction of stockpiled weapons. The book presents and discusses both basic and novel techniques in a variety of areas of analytical chemistry which are relevant to achieving the ultimate destruction of chemical weapons. Presentations address sample collection and preparation, mass spectrometry, chromatographic techniques, NMR, and air monitoring techniques. The work shows that analytical methods do exist to effectively support the destruction of chemical munitions. While further research is needed, the book provides an excellent baseline for further advances in the field.
Author: Publisher: ISBN: Category : Languages : en Pages : 49
Book Description
A "dip and shoot" analytical method was developed for the rapid sampling and desorption electrospray ionization mass spectrometric (DESI-MS) analysis of chemical warfare agents and their hydrolysis products in liquid samples. Sampling was performed by simply dipping fused silica, stainless steel or SPME tips into the organic or aqueous samples. Replicate analyses were completed within several minutes under ambient conditions with no sample pre-treatment, resulting in a significant increase in sample throughput over conventional solid phase microextraction (SPME) sampling and DESI-MS analysis or liquid chromatographic electrospray ionization mass spectrometric (LC-ESI-MS) analysis. The developed sample handling and analysis method was applied to the determination of chemical warfare agent content in samples containing unknown chemical and/or biological warfare agents. Ottawa sand was spiked with mustard, extracted with water and autoclaved to ensure sterility. Mustard was completely hydrolysed during the extraction/autoclave step and thiodiglycol was identified by DESI-MS, with analyses generally being completed within one minute using the "dip and shoot" method developed for the rapid analysis of liquid samples.
Author: Publisher: ISBN: Category : Languages : en Pages : 27
Book Description
A sample handling and analysis method was developed for the identification of chemical warfare agents (as intact compounds or as their hydrolysis products) in samples suspected to contain either chemical or biological warfare agent contamination. The method, based on aqueous extraction, autoclaving of the aqueous extract and LC-ESI-MS analysis was evaluated using three soil samples spiked at the 80 microgram/g level with triethyl phosphate, isopropyl methylphosphonic acid or thiodiglycol. All three compounds were readily extracted and identified following LC-ESI-MS, with triethyl phosphate undergoing some hydrolysis during the autoclaving procedure. This sample handling and analysis method for soil (or other) samples will form a cornerstone of the chemical/biological warfare agent identification strategy being developed at DRDC Suffield to meet National commitments.
Author: Publisher: ISBN: Category : Languages : en Pages : 23
Book Description
This document is a bibliography of literature on analytical methods for the identification and confirmation of chemical warfare agents as developed at Defence Research Establishment Suffield. It contains 150 entries arranged alphabetically by author, all of which have been published in the open scientific literature.
Author: Timothy T. Marrs Publisher: John Wiley & Sons ISBN: 0470013591 Category : Medical Languages : en Pages : 751
Book Description
Chemical Warfare Agents, Second Edition has been totally revised since the successful first edition and expanded to about three times the length, with many new chapters and much more in-depth consideration of all the topics. The chapters have been written by distinguished international experts in various aspects of chemical warfare agents and edited by an experienced team to produce a clear review of the field. The book now contains a wealth of material on the mechanisms of action of the major chemical warfare agents, including the nerve agent cyclosarin, formally considered to be of secondary importance, as well as ricin and abrin. Chemical Warfare Agents, Second Edition discusses the physico-chemical properties of chemical warfare agents, their dispersion and fate in the environment, their toxicology and management of their effects on humans, decontamination and protective equipment. New chapters cover the experience gained after the use of sarin to attack travellers on the Tokyo subway and how to deal with the outcome of the deployment of riot control agents such as CS gas. This book provides a comprehensive review of chemical warfare agents, assessing all available evidence regarding the medical, technical and legal aspects of their use. It is an invaluable reference work for physicians, public health planners, regulators and any other professionals involved in this field. Review of the First Edition: "What more appropriate time for a title of this scope than in the post 9/11 era? ...a timely, scholarly, and well-written volume which offers much information of immense current and…future benefit." —VETERINARY AND HUMAN TOXICOLOGY
Author: Paul A. D'Agostino Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
This document is a bibliography of literature on analytical methods for the identification and confirmation of chemical warfare agents as developed at Defence Research Establishment Suffield. It contains 150 entries arranged alphabetically by author, all of which have been published in the open scientific literature.
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