Author: Anders FernströmPublisher:
ISBN:
Category :
Languages : en
Pages : 94
Book Description
Analysis of a Heat Removal System for an Accelerator Based Neutron Source Used for Boron Neutron Capture Therapy
Author: Anders FernströmDesign of the Target Heat Removal System for an Accelerator-based Neutron Source for Boron Capture Neutron Therapy
Author: Cristian G. MarciulescuPublisher:
ISBN:
Category :
Languages : en
Pages : 152
Book Description
Accelerator-based Neutron Source for Boron Neutron Capture Therapy (BNCT) and Method
Author: Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
A source for boron neutron capture therapy (BNCT) comprises a body of photoneutron emitter that includes heavy water and is closely surrounded in heat-imparting relationship by target material; one or more electron linear accelerators for supplying electron radiation having energy of substantially 2 to 10 MeV and for impinging such radiation on the target material, whereby photoneutrons are produced and heat is absorbed from the target material by the body of photoneutron emitter. The heavy water is circulated through a cooling arrangement to remove heat. A tank, desirably cylindrical or spherical, contains the heavy water, and a desired number of the electron accelerators circumferentially surround the tank and the target material as preferably made up of thin plates of metallic tungsten. Neutrons generated within the tank are passed through a surrounding region containing neutron filtering and moderating materials and through neutron delimiting structure to produce a beam or beams of epithermal neutrons normally having a minimum flux intensity level of 1.0.times. 10.sup. 9 neutrons per square centimeter per second. Such beam or beams of epithermal neutrons are passed through gamma ray attenuating material to provide the required epithermal neutrons for BNCT use.
Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment
Author: Narayan S. HosmanePublisher: World Scientific
ISBN: 9814338672
Category : Medical
Languages : en
Pages : 271
Book Description
The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs have turned the area to be the hottest one and worthy of further investigation with the new clinical trials in the USA and elsewhere.
Optimization of a Moderator Assembly for Use in an Accelerator-based Neutron Source for Boron Neutron Capture Therapy
Author: Jeffrey E. WoollardOptimized Accelerator Based Epithermal Neutron Beams for Boron Neutron Capture Therapy
Author: Rajat KudchadkerPublisher:
ISBN:
Category : Boron-neutron capture therapy
Languages : en
Pages : 418
Book Description
Boron Neutron capture therapy (BNCT) is a form of radiation therapy in which nuclides having a high tendency for capturing thermal neutrons, react by emitting charged particles of short range and leaving essentially no residual radioactivity. If these capture nuclides are selectively introduced into the tumor cells, it is theoretically possible to destroy only the tumor and in the process spare the neighboring healthy tissue. Currently, reactors are the only known source of neutrons being used for BNCT. A number of studies have been done using Monte Carlo computer codes such as MCNP to determine an optimum design of a moderator reflector configuration for an accelerator based neutron source utilizing the Li-7(p, n)Be-7 reaction. To confirm this, benchmark experiments were conducted using both a 2.0 MeV Radio Frequency Quadrupole (RFQ) accelerator and a 2.0 MeV Van de Graaff generator. All previous studies had concluded that 2.5 MeV protons would be optimum, which produces neutron having a maximum energy of 787 keV. For BNCT the desired neutron energies are between 1 eV and nominally 10 keV, i.e. in the epithermal region. These neutrons must hence be moderated to bring them down to the desired energy range. The moderator-reflector assemblies for reactor neutrons or those from 2.5 MeV protons on lithium require a little less than a meter of material to achieve the desired neutron spectrum. This research work focuses on using protons with energies just above the Li-7(p, n)Be-7 reaction threshold. These lower energy protons produce neutrons with a maximum energy of just a few hundred keV requiring much less moderation as compared to the 2.5 MeV proton lithium source. The penalty for the low energy neutron spectrum is the low yield of neutrons per proton as compared to the 2.5 MeV protons on lithium. But, less moderation implies that the patient can be moved closer to the lithium target (neutron source), thus making a more efficient use of the source neutrons. This would partially or wholly compensate for the lower yield per proton. In addition the smaller moderator-reflector assembly would result in less scattering occurring, thereby not degrading the forward directional quality of the beam as much as in current assemblies designed for use with the 2.5 MeV protons on a lithium target.
Advances in Neutron Capture Therapy
Author: R.F. BarthPublisher: Springer Science & Business Media
ISBN: 1461529786
Category : Medical
Languages : en
Pages : 776
Book Description
Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
A Pilot Study of an Epithermal Neutron Source Based on a Low-energy Proton Accelerator for Boron Neutron Capture Therapy
Author: Chang-Kwang Chris WangPublisher:
ISBN:
Category :
Languages : en
Pages : 312
Book Description
An Integrated Design of an Accelerator-based Neutron Source for Boron Neutron Capture Therapy
Author: Michael Christian DobelbowerPublisher:
ISBN:
Category :
Languages : en
Pages : 438
Book Description
Author: Andrew E. Hawk