An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2 PDF Download

Author: Joachim Jose
Publisher: MDPI
ISBN: 3038424129
Category : Medical
Languages : en
Pages : 321

View

Book Description
This book is a printed edition of the Special Issue "An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2" that was published in Pharmaceuticals

Author:
Publisher:
ISBN: 9783038424130
Category : Electronic book
Languages : en
Pages :

View

Book Description

Author: Angela Gorgoglione
Publisher: MDPI
ISBN: 3039282107
Category : Science
Languages : en
Pages : 94

View

Book Description
heavily Environmental mathematical models represent one of the key aids for scientists to forecast, create, and evaluate complex scenarios. These models rely on the data collected by direct field observations. However, assembly of a functional and comprehensive dataset for any environmental variable is difficult, mainly because of i) the high cost of the monitoring campaigns and ii) the low reliability of measurements (e.g., due to occurrences of equipment malfunctions and/or issues related to equipment location). The lack of a sufficient amount of Earth science data may induce an inadequate representation of the response’s complexity in any environmental system to any type of input/change, both natural and human-induced. In such a case, before undertaking expensive studies to gather and analyze additional data, it is reasonable to first understand what enhancement in estimates of system performance would result if all the available data could be well exploited. Missing data imputation is an important task in cases where it is crucial to use all available data and not discard records with missing values. Different approaches are available to deal with missing data. Traditional statistical data completion methods are used in different domains to deal with single and multiple imputation problems. More recently, machine learning techniques, such as clustering and classification, have been proposed to complete missing data. This book showcases the body of knowledge that is aimed at improving the capacity to exploit the available data to better represent, understand, predict, and manage the behavior of environmental systems at all practical scales.

Author: Francisco M. Vega
Publisher:
ISBN: 9783036530543
Category :
Languages : en
Pages : 167

View

Book Description
This book is a printed edition of the Special Issue "Non-canonical Kinases and Substrates in Cancer Progression" that was published in the scientific journal Cancers. It was edited by Francisco M. Vega, Ph.D. from the University of Seville in Spain. It brings together the latest views and original research on non-canonical protein kinases, substrates, and scaffolds.

Author: Khalil Ahmed
Publisher: Springer Science & Business Media
ISBN: 9780792376668
Category : Science
Languages : en
Pages : 200

View

Book Description
Signal Transduction through phosphorylation and dephosphorylation of proteins in the cell is now a well-recognized mechanism involved in countless physiological and pathological processes. Consequently, the enzymes, known as protein kinases, which catalyze the phosphorylation of proteins, are critical regulators of cellular events. One of these protein kinases is the protein kinase CK2 (also known as casein kinase 2) that has been implicated in multiple functions including control of cell growth and proliferation. CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.

Author: James E. Barrett
Publisher: Springer Nature
ISBN: 3030353621
Category : Medical
Languages : en
Pages : 466

View

Book Description
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Author: Joëlle Roche
Publisher: MDPI
ISBN: 3038427934
Category : Science
Languages : en
Pages : 261

View

Book Description
This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers

Author: World Health Organization
Publisher:
ISBN: 9789241565721
Category :
Languages : en
Pages : 224

View

Book Description
The World Malaria Report 2019 provides a comprehensive update on global and regional malaria data and trends. The report tracks investments in malaria programs and research as well as progress across all intervention areas: prevention, diagnosis, treatment, elimination, and surveillance. It also includes dedicated chapters on the consequences of malaria on maternal infant and child health the "High Burden to High Impact" approach as well as biological threats to the fight against malaria. The 2019 report is based on information received from more than 80 countries and areas with ongoing malaria transmission. This information is supplemented by data from national household surveys and databases held by other organizations.

Author: Vasilis Vasiliou
Publisher: Springer
ISBN: 3319987887
Category : Medical
Languages : en
Pages : 274

View

Book Description
Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells. More specifically, it delves into the effects of alcohol consumption and thyroid cancer, CD133+ progenitor cells, carcinogenic iron accumulation, developmental morphogens, and cancer-inducing epigenetic changes. Alcohol and Cancer: Proceedings of the Third International Conference is a timely update to Biological Basis of Alcohol-Induced Cancer, which followed the Second Alcohol and Cancer Conference, compiling cutting-edge research from graduate students, young scientists, and researchers. It is ideal for graduate students and researchers in oncology, hepatology, epigenetics, and alcohol consumption.

Author: Vincenzo Zappia
Publisher: Springer Science & Business Media
ISBN: 1475732309
Category : Medical
Languages : en
Pages : 313

View

Book Description
This volume includes contributions presented at the Second International Sym posium on Nutrition and Cancer, held in Naples, Italy, in October 1998 at the National Tumor Institute "Fondazione Pascale." During the Conference, experts from different disciplines discussed pivotal and timely subjects on the interactions between human nutrition and the development of malignancies. Comparing the themes of this Meeting with those discussed at the First Sympo sium in 1992, the major scientific advancements certainly derive from the extensive use of molecular approaches to perform research in nutrition. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. On the other hand, the relationships between diet and cancer are quite intricate and complex; it is difficult, and at the same time not methodologically correct, to reduce them to simple terms. Metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all pieces of the same puzzle.