Author: Hsiang-Ching KungPublisher:
ISBN:
Category :
Languages : en
Pages : 300
Book Description
An Approach to the Total Synthesis of (+)-lythranidine and a Study of the Addition of Nitrones to Indoles
Author: Hsiang-Ching KungAn Approach Towards the Total Synthesis of Lythranidine
Author: Zahra-Shahla Mahdavi O'BrienPublisher:
ISBN:
Category :
Languages : en
Pages : 174
Book Description
Dissertation Abstracts International
Author: Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 714
Book Description
A Nitrone-based Synthesis of Lythranidine
Author: Chetan PanditPart I: Synthesis of Pyrrolo[1,2-a]indoles Part II: Studies Towards Arboflorine
![Part I: Synthesis of Pyrrolo[1,2-a]indoles Part II: Studies Towards Arboflorine PDF](https://books.google.com/books/content/images/frontcover/1-zwwQEACAAJ?fife=w80-h100)
Author: Michael B. JohansenPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Part one of this thesis focuses on the synthesis of pyrrolo[1,2-a]indoles from nitrones and 1,1-cyclopropanediesters, by way of tetrahydro-1,2-oxazines. A five step synthetic sequence through tetrahydro-1,2-oxazine synthesis, intramolecular Heck reaction, Krapcho dealkoxycarbonylation, reductive N-O bond cleavage, and acid catalyzed transannular alcohol displacement, is developed to access the desired pyrrolo[1,2-a]indoles. Part two of this thesis details the functionalization of indoles by installation of a malonate moiety, by means of copper catalyzed carbenoid reactivity. A wide range of malonyl indoles with varying substitution patterns is shown to be accessible through the developed method. The final chapter focuses on the application of this reaction in a biomimetic approach towards the total synthesis of the indole alkaloid arboflorine. This reaction provided access to an advanced intermediate which allowed for the study of a key Mannich ring closure step that was proposed in the postulated biogenesis of the natural product. The current synthetic sequence includes the copper catalyzed malonyl carbenoid insertion, reduction of a pyridinium salt, reductive ammination, and a Polonovski-Potier reaction to install and mask an iminium motif. As of yet, the proposed Mannich reaction has been unsuccessful in securing the required azepane ring.
Comprehensive Dissertation Index
Author: Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 754
Book Description
American Doctoral Dissertations
Author: Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 696
Book Description
American Chemical Society Directory of Graduate Research, 1987
Author: American Chemical Society, Committee on Professional Training StaffPublisher:
ISBN: 9780841214187
Category : Science
Languages : en
Pages : 1390
Book Description
Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards
Author: Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 1250
Book Description
Theses on any subject submitted by the academic libraries in the UK and Ireland.
Cycloadditions in Bioorthogonal Chemistry
Author: Milan VrabelPublisher: Springer
ISBN: 9783319296845
Category : Science
Languages : en
Pages : 0
Book Description
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.