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Author: J. K. Aronson Publisher: ISBN: Category : Case studies Languages : en Pages : 448
Book Description
'This book is a delight, from start to finish, touching upon all manner of fascinating topics...a most enjoyable text.' New Scientist'It would be invidious for the reviewer to select for special mention any particular chapter from Aronson's history and critique because each one is so well-written, so thoroughly researched and so full of fresh material...With three indexes and over 250 references to complete the work we canrightly say that the Oxford pharmacologist has written a classic about a classic.' Journal of the Royal College of General Practitioners
Author: J. K. Aronson Publisher: ISBN: Category : Case studies Languages : en Pages : 448
Book Description
'This book is a delight, from start to finish, touching upon all manner of fascinating topics...a most enjoyable text.' New Scientist'It would be invidious for the reviewer to select for special mention any particular chapter from Aronson's history and critique because each one is so well-written, so thoroughly researched and so full of fresh material...With three indexes and over 250 references to complete the work we canrightly say that the Oxford pharmacologist has written a classic about a classic.' Journal of the Royal College of General Practitioners
Author: Andrew Cunningham Publisher: Cambridge University Press ISBN: 9780521382359 Category : Medical Languages : en Pages : 346
Book Description
A series of essays on the development of medicine in the century of the Enlightenment, illustrating the decline in the role of religion in medical thinking, and the increased use of reason.
Author: Walter Sneader Publisher: John Wiley & Sons ISBN: 9780471899792 Category : Medical Languages : en Pages : 484
Book Description
This edition provides expanded coverage of pre-20th century drugs, including emphasis on setting chapters in a wide historical and social context.
Author: E. Erdmann Publisher: Springer Science & Business Media ISBN: 3662112922 Category : Medical Languages : en Pages : 544
Book Description
The bicentenary of William Withering's now famous medical report entitled "An Account of the Foxglove and Some of its Medical Uses" has given us the occasion to analyze the state of the art. Cardiac glycosides in 1985 are considered tobe the basis for medical treatment of myocardial failure, together with diuretics and vasodilators in the more severe cases. Nevertheless, the controversy as to their exact place in the treatment of heart failure with sinus rhythm has never ceased. Although cardiac glycosides are of unquestionable value in tachycardia caused by atrial fibrillation or atrial flutter, the chronic use of these drugs in sinus rhythm is not generally accepted. The development of tolerance has been reported. It is of interest that Withering hirnself wrote: "-let it (foxglove) be continued until it either acts on the kidneys, the stomach, the pulse, or the bowels; Iet it be stopped upon the first appearance of any of these effects, and I will maintain that the patient will not suffer from its exhibition, nor the practitioner be disappointed in any reasonable expectation. " In West Germany alone, more than three million patients (about 5% of the total population) are constantly taking cardiac glycosides. These drugs are the most prescribed medicaments in many countries. Thus, we considered it worthwhile and necessary to review in a critical way today's knowledge about the foxglove; to report new findings and to evaluate old Statements.
Author: Roy Porter Publisher: Cambridge University Press ISBN: 0521864267 Category : Medical Languages : en Pages : 11
Book Description
Against the backdrop of unprecedented concern for the future of health care, 'The Cambridge History of Medicine' surveys the rise of medicine in the West from classical times to the present. Covering both the social and scientific history of medicine, this volume traces the chronology of key developments and events.
Author: Derek J. Chadwick Publisher: John Wiley & Sons ISBN: 0470514647 Category : Science Languages : en Pages : 290
Book Description
A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which are used for some of the most potent drugs in Western medicine.
Author: Steven Piantadosi Publisher: John Wiley & Sons ISBN: 1118959221 Category : Mathematics Languages : en Pages : 1064
Book Description
Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at https://risccweb.csmc.edu/biostats/. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.
Author: J. K. Aronson
Author: J. K. Aronson
Author: William Withering
Author: Andrew Cunningham
Author: Walter Sneader
Author: E. Erdmann
Author: 
Author: Roy Porter
Author: Cynthia Saltzman
Author: Derek J. Chadwick
Author: Steven Piantadosi