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Author: Harry Levine Publisher: Royal Society of Chemistry ISBN: 1847550118 Category : Technology & Engineering Languages : en Pages : 397
Book Description
During the past decade, the importance of amorphous water-soluble substances has been increasingly recognised within the food and pharmaceutical industries. In response, Amorphous Food and Pharmaceutical Systems brings together current leading experts to contribute to this unique cross-disciplinary account of the subject. Coverage includes: water-compatible amorphous solids (physical, chemical behaviour), low water content systems (water as plasticizer); applications in food and pharmaceutical sciences and industries (processing and stability) along with state-of-the-art technology in food and pharmaceutical systems. This timely publication will be welcomed by academic and industrial researchers and professionals in the pharmaceuticals, food, materials and polymer sciences.
Author: Harry Levine Publisher: Royal Society of Chemistry ISBN: 1847550118 Category : Technology & Engineering Languages : en Pages : 397
Book Description
During the past decade, the importance of amorphous water-soluble substances has been increasingly recognised within the food and pharmaceutical industries. In response, Amorphous Food and Pharmaceutical Systems brings together current leading experts to contribute to this unique cross-disciplinary account of the subject. Coverage includes: water-compatible amorphous solids (physical, chemical behaviour), low water content systems (water as plasticizer); applications in food and pharmaceutical sciences and industries (processing and stability) along with state-of-the-art technology in food and pharmaceutical systems. This timely publication will be welcomed by academic and industrial researchers and professionals in the pharmaceuticals, food, materials and polymer sciences.
Author: Harry Levine Publisher: Royal Society of Chemistry ISBN: 9780854048663 Category : Medical Languages : en Pages : 408
Book Description
During the past decade, the importance of amorphous water-soluble substances has been increasingly recognised within the food and pharmaceutical industries. In response, Amorphous Food and Pharmaceutical Systems brings together current leading experts to contribute to this unique cross-disciplinary account of the subject. Coverage includes: water-compatible amorphous solids (physical, chemical behaviour), low water content systems (water as plasticizer); applications in food and pharmaceutical sciences and industries (processing and stability) along with state-of-the-art technology in food and pharmaceutical systems. This timely publication will be welcomed by academic and industrial researchers and professionals in the pharmaceuticals, food, materials and polymer sciences.
Author: Marzena Rams-Baron Publisher: Springer ISBN: 3319720023 Category : Science Languages : en Pages : 234
Book Description
This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.
Author: Ann Newman Publisher: John Wiley & Sons ISBN: 1118455207 Category : Science Languages : en Pages : 502
Book Description
Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations • Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach • Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world
Author: Navnit Shah Publisher: Springer ISBN: 1493915983 Category : Medical Languages : en Pages : 702
Book Description
This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
The amorphous solids can be used in a number of applications such as food, bio-preservation, organic electronics, and drugs. In pharmaceutical systems, amorphous drugs have greater solubility and bioavailability than their crystalline counterparts, giving them an important function in drug delivery formulation. Recent studies have compared surface-enhanced crystallization to bulk crystal growth. The surface crystal growth rate can be orders of magnitude faster than growth rate in the bulk. It has been shown that surface-enhanced crystallization is a common phenomenon on molecular glasses. Thus, it is significant to understand the mechanism of fast surface crystallization on molecular glasses. We report that the onset of fluidity generally disrupts fast surface crystal growth in indomethacin(a IMC), nifedipine (NIF), and o-terphenyl (OTP). The severity of this inhibition depends on crystal morphology. Segregated needles are more susceptible to the liquid flow than crystals that grow in compact domains. With scanning electron microscopy (SEM) and atomic force microscopy (AFM), we characterize the surface evolution of depletion zones around growing a crystal. We find that the observed depletion zones are well reproduced by the known coefficients of surface diffusion and crystal growth rate. Finally, the effect of special confinement on surface crystal growth was performed. Surface crystal growth was disrupted if the width is reduced to below several micrometers or if the glass film is thinner than the depth of depletion zones. Similarly, surface crystallization kinetics is affected by glass thickness or substrate. Surface crystal growth is initially fast, but slows over time if the glass film is thinner than approximately 10 um. All these effects reflect the environmental perturbation of surface crystal growth. The slowdown of surface crystal growth in microns-thick films may be caused by the propagation of cracks created by a fracture in the bulk. These results are relevant to understand the stability of amorphous solids against surface crystallization in formulations and product development.
Author: Felix Franks Publisher: Royal Society of Chemistry ISBN: 1847557708 Category : Medical Languages : en Pages : 219
Book Description
Freeze-drying, in the past popular in the food industry, has more recently been adopted by the pharmaceutical industry as a standard method for the production of stable solid preparations. Freeze-drying of Pharmaceuticals and Biopharmaceuticals is the first book to specifically describe this process, as related to the pharmaceutical industry. The emphasis of this book is on the properties of the materials processed, how effective formulations are arrived at, and how they are stored and marketed. Beginning with a historical overview of the process, Freeze-drying of Pharmaceuticals and Biopharmaceuticals briefly describes the processes and equipment involved, including: the physics, chemistry and biochemistry associated with freezing, aspects of formulation development, primary and secondary drying; the economics and engineering of scaling up; and, most importantly, attributes of the dried product. It also discusses in detail the science behind freeze-drying, such as the properties of crystalline and amorphous solids. The book concludes with selected case studies and discusses the future of freeze-drying, advances in alternative drying methods, and concludes with an extensive bibliography. This book, written by a leading expert in the field, is aimed primarily at product and process developers in the biopharmaceutical industry and academia.
Author: Harry G. Brittain Publisher: CRC Press ISBN: 1420073222 Category : Medical Languages : en Pages : 656
Book Description
Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism a
Author: Harry Levine
Author: Harry Levine
Author: Harry Levine
Author: Marzena Rams-Baron
Author: Michael Devlin
Author: Ann Newman
Author: Navnit Shah
Author: 
Author: Mridul Majumder
Author: Felix Franks
Author: Harry G. Brittain