Author: Gerald J. MizejewskiPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 392
Book Description
Alpha-fetoprotein and Congenital Disorders
Author: Gerald J. MizejewskiPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 392
Book Description
Maternal Serum Alpha-fetoprotein
Author: Genetic Disorders and the Fetus
Author: Aubrey MilunskyPublisher: Springer Science & Business Media
ISBN: 1468434381
Category : Medical
Languages : en
Pages : 718
Book Description
Technological advances continue to expand the number of genetic disorders that can be diagnosed in utero. Utilization of this new technology has de manded special expertise available in relatively few academic centers. As these new applications have become more widespread so have the realities of the medicolegal implications. Notwithstanding the laboratory challenges, most legal action, at least in the United States, has arisen from the physician's failure to inform a patient about the risks of a genetic disorder or the oppor tunities presented by prenatal diagnosis. Hence an extensive thorough reex amination of the subject seems appropriate and timely. The steady escalation in the number of prenatal genetic studies now being done in the western world makes it imperative for the physician to have a thorough comprehension of the subject in its entirety. I am, therefore, fortu nate in having colleagues who as acknowledged experts have shared their knowledge and experience in order to make this volume a major critical repository of facts and guidance about prenatal genetic diagnosis. The subject matter ranges from a consideration of required genetic counseling through the intricacies of establishing prenatal diagnoses. Special attention is focused on new advances using ultrasound, a-fetoprotein, fetoscopy, and first trimester diagnosis. Both ethical and legal implications are discussed in detail, as is the development of public policy.
Alpha-fetoprotein and Its Receptor in Fixing the Cancer Brakes
Author: Vladimir N. PakPublisher: Cambridge Scholars Publishing
ISBN: 1527567729
Category : Science
Languages : en
Pages : 209
Book Description
This book examines the crucial role of a unique alpha-fetoprotein (AFP) in the treatment of cancer. AFP can deliver toxins through specific receptors re-expressed in the majority of cancer cells, serving as a targeted chemotherapy. More importantly, AFP+toxin harnesses the patient’s immune system in order to attack cancer. Depleting the regulatory top monocyte-derived suppressor cells (MDSCs) activates both the innate and adaptive immune responses. The thoroughly chosen toxins switch on apoptosis in MDSCs, restore the broken one in cancer cells, and destroy them naturally without any harmful by-products. Injections with AFP+toxin preparations have shown promising results in animals and the treatment of cancer patients. In addition to this breakthrough, the book also discusses the peroral administration of porcine AFP non-covalent complexes with selected toxins in patients with metastases. It will appeal to science researchers, clinicians, and medical students, as well as the more general reader.
Prevention of Neural Tube Defects
Author: Barbara F. CrandallPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 296
Book Description
The California Expanded Alpha-fetoprotein Screening Program
Author: Human Alpha-fetoprotein
Author: Bent Nørgaard-PedersenPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 64
Book Description
Prevention of Physical and Mental Congenital Defects: Epidemiology, early detection and therapy, and environmental factors
Author: Publisher:
ISBN:
Category : Abnormalities, Human
Languages : en
Pages : 528
Book Description
Alpha-Fetoprotein
Author: Nisha LakhiPublisher: Nova Science Publishers
ISBN: 9781634848756
Category : Alpha fetoproteins
Languages : en
Pages : 0
Book Description
Alpha-fetoprotein (AFP) has many applications across various disciplines. This oncofetal protein is routinely used by clinicians for antenatal testing as well for the screening and treatment monitoring of certain malignances. Innovative research using AFP has also been very promising. Recent developments include the use of AFP or its recombinant fragments for drug delivery to cancer cells, as well as for the engineering of cancer vaccines and T cell immunotherapies. The anti-estrogenic potential of AFP has also been utilised to develop drugs directed against estrogen receptor positive malignancies. This book is divided into five sections. In Section One, the history of AFP is recollected, and the role of AFP in normal and pathological conditions is explored. Section Two and Three focus on the utility of AFP during pregnancy. In Section Two, the use of routine maternal serum AFP screening for detection of chromosomal aneuploidies and neural tube defects in normal pregnancies and pregnancies with pre-existing disease is discussed; the potential use of AFP for the detection of preeclampsia is also reviewed. Section Three explores the pathogenesis and data linking unexplained elevations of AFP to adverse obstetrical outcomes. Section Four presents chapters that discuss AFP ligand binding, receptor targeting, and drug delivery strategies. Finally, Section Five serves to explain the regulatory roles of AFP, its use in immunotherapy, and in the development of cancer vaccines. The aim of this book is to bring together some of the great research and clinical insights that currently surround AFP. The target audiences for this book are basic science researchers as well as clinicians.
Before Birth
Author: Elena O. NightingalePublisher: Harvard University Press
ISBN: 9780674063907
Category : Bioethics
Languages : en
Pages : 144
Book Description
'An extremely informative, well-written and amply diagrammed book, which should be of great value to laypersons and their physicians who require further genetic review and background for present and future gene therapies.' - Theodore Kushnick, M.D., Journal of the American Medical Association.