Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction PDF Download

Author: David Raeburn
Publisher: Springer
ISBN: 303487362X
Category : Medical
Languages : en
Pages : 425

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Author: David Raeburn
Publisher: Birkhäuser
ISBN: 3034875045
Category : Medical
Languages : en
Pages : 547

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Author: Jerome Brody
Publisher: CRC Press
ISBN: 9780824788131
Category : Science
Languages : en
Pages : 684

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This reference offers detailed discussions of the basic aspects of signal transduction, and examines their applications in lung cell biology. Providing an overview of current research directions, Signal Transduction in Lung Cells covers: the structure and function of receptors; the structure and regulation of G proteins; second messenger systems including kinases and phosphatases; airway and alveolar cells; smooth muscle cells; inflammatory and immune cells; muscle tone, ion channels, growth factors and cytokines.;With over 1900 literature citations and figures, Signal Transduction in Lung Cells is intended as a resource for pulmonologists, physiologists, molecular and cell biologists, pharmacologists, and graduate and medical school students in these disciplines.

Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589

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New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1064

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Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309

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The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author: Stephen G. Farmer
Publisher: Academic Press
ISBN: 0080542522
Category : Medical
Languages : en
Pages : 371

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Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.

Author: Michael Barany
Publisher: Elsevier
ISBN: 0080527892
Category : Science
Languages : en
Pages : 455

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This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.

Author: David Raeburn
Publisher: Birkhäuser
ISBN: 3034876815
Category : Medical
Languages : en
Pages : 350

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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1104

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