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Author: Susan Boc Publisher: ISBN: Category : Languages : en Pages : 283
Book Description
The overall aim of this research project was to develop surfactant dry powder formulations and devices for efficient delivery of aerosol formulations to infants using the excipient enhanced growth (EEG) approach. Use of novel formulations and inline delivery devices would allow for more efficient treatment of infants suffering from neonatal respiratory distress syndrome and bronchiolitis. A dry powder aerosol formulation has been developed using the commercial product, Survanta ® (beractant) and EEG technology to produce micrometer-sized hygroscopic particles. Spray drying and formulation parameters were initially determined with dipalmitoylphosphatidylcholine (DPPC, the dominant phospholipid in pulmonary surfactant), which produced primary particles 1 mm in size with a mass median aerodynamic diameter of 1-2 mm. Investigation of dry powder dispersion enhancers and alcohol concentration on the effect of powder aerosol characteristics were performed with the Survanta-EEG formulation. The optimal formulation consisted of Survanta®, mannitol and sodium chloride as hygroscopic excipients, and leucine as the dry powder dispersion enhancer, prepared in 20% v/v ethanol/water. The powders produced primary particles of 1 mm with>50% of the particles less than 1 mm. The presence of surfactant proteins and surface activity were demonstrated with the Survanta-EEG formulation following processing. A novel containment unit dry powder inhaler (DPI) was designed for delivery of the surfactant-EEG formulation using a low volume of dispersion air. Studies explored optimization of air entrainment pathway, inlet hole pattern, delivery tube internal diameter and length. With 3-10 mg fill masses of spray dried surfactant powder, the DPI enabled delivery of>2 mg using one 3-mL actuation of dispersion air. Overall, it was possible to deliver>85% of the loaded fill mass using three actuations. Nebulized aerosol formulations are characterized with low delivered doses. Using a novel mixer-heater delivery system, the highest estimated percent lung dose achieved during realistic in vitro testing of a Survanta-EEG formulation aerosolized with a commercial mesh nebulizer was when nebulization was synchronized with inhalation of the breathing profile. Design changes to the mixer-heater system eliminated the need for synchronization, achieving an estimated percent lung dose of 31% of the nominal, an improvement compared with existing systems that achieve approximately
Author: Susan Boc Publisher: ISBN: Category : Languages : en Pages : 283
Book Description
The overall aim of this research project was to develop surfactant dry powder formulations and devices for efficient delivery of aerosol formulations to infants using the excipient enhanced growth (EEG) approach. Use of novel formulations and inline delivery devices would allow for more efficient treatment of infants suffering from neonatal respiratory distress syndrome and bronchiolitis. A dry powder aerosol formulation has been developed using the commercial product, Survanta ® (beractant) and EEG technology to produce micrometer-sized hygroscopic particles. Spray drying and formulation parameters were initially determined with dipalmitoylphosphatidylcholine (DPPC, the dominant phospholipid in pulmonary surfactant), which produced primary particles 1 mm in size with a mass median aerodynamic diameter of 1-2 mm. Investigation of dry powder dispersion enhancers and alcohol concentration on the effect of powder aerosol characteristics were performed with the Survanta-EEG formulation. The optimal formulation consisted of Survanta®, mannitol and sodium chloride as hygroscopic excipients, and leucine as the dry powder dispersion enhancer, prepared in 20% v/v ethanol/water. The powders produced primary particles of 1 mm with>50% of the particles less than 1 mm. The presence of surfactant proteins and surface activity were demonstrated with the Survanta-EEG formulation following processing. A novel containment unit dry powder inhaler (DPI) was designed for delivery of the surfactant-EEG formulation using a low volume of dispersion air. Studies explored optimization of air entrainment pathway, inlet hole pattern, delivery tube internal diameter and length. With 3-10 mg fill masses of spray dried surfactant powder, the DPI enabled delivery of>2 mg using one 3-mL actuation of dispersion air. Overall, it was possible to deliver>85% of the loaded fill mass using three actuations. Nebulized aerosol formulations are characterized with low delivered doses. Using a novel mixer-heater delivery system, the highest estimated percent lung dose achieved during realistic in vitro testing of a Survanta-EEG formulation aerosolized with a commercial mesh nebulizer was when nebulization was synchronized with inhalation of the breathing profile. Design changes to the mixer-heater system eliminated the need for synchronization, achieving an estimated percent lung dose of 31% of the nominal, an improvement compared with existing systems that achieve approximately
Author: World Health Organization Publisher: World Health Organization ISBN: 924006785X Category : Medical Languages : en Pages : 14
Book Description
The World Health Organization (WHO) has now developed a target product profile (TPP) for the minimal and optimal characteristics of an aerosolized surfactant that can be used for neonates with respiratory distress syndrome (RDS) in low- and middle-income countries (LMICs). The purpose of the TPP is to guide product developers about key test characteristics and performance specifications that will meet the needs of end users in LMICs. It describes the minimal and optimal characteristics of an aerosolized surfactant for treatment of RDS in newborns in LMICs. The intended target audience is doctors, nurses, pharmacists, administrators, procurement officers, program managers, policy makers, members of academic organizations who care for preterm neonates.
Author: Drew Myers Publisher: John Wiley & Sons ISBN: 0471746061 Category : Technology & Engineering Languages : en Pages : 398
Book Description
A general introduction to surfactants, surface activity, and surfactant applications Important advances in the tools available for studying the activity of surfactants has significantly increased scientific understanding of interfaces at the molecular level. However, there is still much to be learned. In this Third Edition of the successful classic, author and expert Drew Myers combines the latest information available in the field of surfactants with his original, accessible text on the subject. Now fully updated to reflect recent developments in working with surfactants in both model and practical systems, the Third Edition of Surfactant Science and Technology provides a solid introduction to the field of surfactant science. Written especially for beginners and nonspecialists who would like a practical but not necessarily comprehensive knowledge of the field, this clear, cogent text conveys the most fundamental and useful concepts of surfactant action and application. New chapters bring readers up to date on current biological and medical applications of surfactants, as well as applications in food science, cosmetics, and other areas. In addition to new chapters, Surfactant Science and Technology includes illustrative problems at the end of each chapter. These problems explain concepts discussed and stimulate imaginative solutions on the part of the reader. A helpful bibliography of supplementary resources for readers who desire more detail has also been included. Surfactant Science and Technology, Third Edition is an invaluable resource for surface and polymer chemists, chemical and industrial engineers, and a wide range of chemistry students.
Author: Anthony J. Hickey Publisher: CRC Press ISBN: 1351660519 Category : Medical Languages : en Pages : 546
Book Description
Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.
Author: Olasehinde Owoseni Publisher: BoD – Books on Demand ISBN: 1837687064 Category : Technology & Engineering Languages : en Pages : 168
Book Description
This book presents detailed fundamentals of surfactant systems and links these fundamentals to emerging perspectives in the field of surfactant science. Key topics include environmentally friendly surfactants, ionic liquid-based surfactants, chemically enhanced oil recovery, synergy of surfactants with clay minerals, and reactions in microheterogeneous surfactant systems. This book is an excellent resource for students, researchers, and industry professionals.
Author: Erik Kissa Publisher: CRC Press ISBN: 9780824704728 Category : Science Languages : en Pages : 650
Book Description
A discussion of the synthesis, problems, theories and applications of fluorinated surfactants, this second edition is updated with four new chapters on repellency and protection against soiling and staining and over 2900 references, equations, and drawings (800 more than the previous edition). It lists alphabetically and explores numerous applications of fluorinated surfactants. Called "...a most useful introduction to these fascinating materials" by the Journal of Dispersion Science and Technology and "...a coherent and stimulating handbook...the most useful book in the fluorinated surfactants field to date. Recommended." by the Journal of the Chemical Society, Faraday Transactions - this book is a source of factual data, methods of manufacture, and chemical structures for the surfactant scientist and user.
Author: Susan Boc
Author: Susan Boc
Author: World Health Organization
Author: Saurabhkumar J. Desai
Author: Drew Myers
Author: Robert Joseph Sweeney
Author: Anthony J. Hickey
Author: Olasehinde Owoseni
Author: Erik Kissa
Author: Donald L. Shapiro
Author: Jariya Sukhapan