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Author: PATHAN AZHER KHAN Publisher: Pristyn Research Solutions ISBN: 8197170134 Category : Science Languages : en Pages : 54
Book Description
This book comprehensively examines the landscape of immunotherapeutic modalities in cancer treatment, with a specific focus on Chimeric Antigen Receptor (CAR) T-cell therapy, immune checkpoint inhibitors, and other innovative approaches. The CAR T-cell therapy represents a groundbreaking approach wherein T-cells are genetically engineered to recognize and eradicate tumor cells expressing specific antigens. The book briefly discussed the clinical applications and challenges associated with CAR T-cell therapy, case studies highlighting its remarkable efficacy in malignancies, and emerging potential in solid tumors. Additionally, immune checkpoint inhibitors have transformed the treatment of various cancers by disrupting inhibitory signalling pathways and reinvigorating antitumor immune responses. This book explores the mechanisms, clinical efficacy, and challenges of immune checkpoint blockade, including strategies to overcome resistance and improve patient outcomes. Furthermore, it promises other innovative immunotherapeutic strategies, such as tumor vaccines, cytokine therapies, and adoptive cell transfer. Personalized Approaches emphasize their potential synergies and future directions in combination with existing modalities. Overall, this book provides insights into the evolving landscape of cancer immunotherapy, emphasizing the significant strides made in improving patient outcomes and the ongoing efforts to optimize treatment efficacy and durability while minimizing adverse effects.
Author: PATHAN AZHER KHAN Publisher: Pristyn Research Solutions ISBN: 8197170134 Category : Science Languages : en Pages : 54
Book Description
This book comprehensively examines the landscape of immunotherapeutic modalities in cancer treatment, with a specific focus on Chimeric Antigen Receptor (CAR) T-cell therapy, immune checkpoint inhibitors, and other innovative approaches. The CAR T-cell therapy represents a groundbreaking approach wherein T-cells are genetically engineered to recognize and eradicate tumor cells expressing specific antigens. The book briefly discussed the clinical applications and challenges associated with CAR T-cell therapy, case studies highlighting its remarkable efficacy in malignancies, and emerging potential in solid tumors. Additionally, immune checkpoint inhibitors have transformed the treatment of various cancers by disrupting inhibitory signalling pathways and reinvigorating antitumor immune responses. This book explores the mechanisms, clinical efficacy, and challenges of immune checkpoint blockade, including strategies to overcome resistance and improve patient outcomes. Furthermore, it promises other innovative immunotherapeutic strategies, such as tumor vaccines, cytokine therapies, and adoptive cell transfer. Personalized Approaches emphasize their potential synergies and future directions in combination with existing modalities. Overall, this book provides insights into the evolving landscape of cancer immunotherapy, emphasizing the significant strides made in improving patient outcomes and the ongoing efforts to optimize treatment efficacy and durability while minimizing adverse effects.
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309490898 Category : Medical Languages : en Pages : 89
Book Description
In recent years, significant progress has been made in the clinical development and use of various types of cancer immunotherapy, all of which rely on the immune system to fight cancer. The majority of new cancer drug applications submitted to the Food and Drug Administration (FDA) are for immunotherapies or combinations involving immunotherapies. One type of immunotherapy is an immune checkpoint inhibitor. Cells in the human body have proteins that regulate the immune system response to foreign invaders (e.g., cancer cells, microorganisms). However, cancer cells can coopt these "checkpoint" proteins and thwart the immune system's ability to recognize and attack cancer cells. To help promote an immune response to cancer, researchers have developed immune checkpoint inhibitors that enable T-cells to recognize cancer cells as foreign and to prevent deactivation of an immune system response. To examine the challenges and opportunities to develop combination cancer therapies that include immune checkpoint inhibitors, the National Cancer Policy Forum held a workshop on July 16â€"17, 2018, in Washington, DC. This workshop convened stakeholders with a broad range of expertise, including cancer researchers, clinicians, patient advocates, and representatives from industry, academia, and government. This publication summarizes the presentations and discussions from the workshop.
Author: Azhar ul Haque Sario Publisher: Azhar ul Haque Sario ISBN: 3384338103 Category : Medical Languages : en Pages : 175
Book Description
Unlock the future of cancer treatment with "Immunotherapy Cancer Battle: Innovative Approaches for Success." This comprehensive guide dives deep into the revolutionary world of cancer immunotherapy, exploring the cutting-edge strategies and breakthroughs that are reshaping how we combat this relentless disease. From the foundational discoveries of immune checkpoint inhibitors to the advanced engineering of CAR T-cells, this book provides an in-depth journey through the evolution of immunotherapy. Chapter by chapter, you’ll uncover the remarkable stories behind these treatments—how they were developed, the science that drives them, and the incredible impact they've had on patients' lives. You'll learn about the groundbreaking clinical trials that have led to life-changing approvals for various cancers, offering hope where there once was none. But this book isn't just about the successes—it's also about the ongoing challenges and innovations in the field. You’ll explore how scientists and clinicians are continually pushing the boundaries, combining immunotherapies with traditional treatments like chemotherapy and radiation to maximize efficacy. You’ll delve into the world of tumor-infiltrating lymphocytes (TILs) and their potential for personalized treatment, as well as the promise of cancer vaccines that could one day prevent or treat cancers with unparalleled precision. Ever wondered how viruses might be used to fight cancer? You'll find out in the chapter on oncolytic virus therapy, where viruses are re-engineered to selectively infect and destroy cancer cells. Plus, you’ll read about the exciting developments in adoptive cell transfer (ACT) therapies, including T-cells, natural killer (NK) cells, and cytokine-induced killer (CIK) cells, all working together to diversify and strengthen our immune responses. The book also covers innovative strategies like bispecific antibodies, which simultaneously engage two different targets, and next-generation immune checkpoints that go beyond PD-1 and CTLA-4 to offer new hope for patients. You'll gain insight into the complexities of the tumor microenvironment and how modulating it can enhance the effectiveness of immunotherapies, creating a more hostile environment for cancer to thrive. And that's not all. "Immunotherapy Cancer Battle" takes you through the futuristic applications of nanotechnology and epigenetic modulation in cancer treatment, showcasing how these cutting-edge fields are being harnessed to boost immune responses and deliver therapies more precisely than ever before. You’ll discover the potential of precision immunotherapy, which tailors treatments based on individual genetic and molecular profiles, and the role of artificial intelligence in optimizing these personalized strategies. The book also doesn’t shy away from the real-world challenges of immunotherapy, including the management of immune-related adverse events (irAEs) and the unique considerations required for pediatric patients. It explores the mechanisms behind resistance to immunotherapy and the strategies being developed to overcome these barriers, ensuring more patients can benefit from these innovative treatments. In its final chapters, "Immunotherapy Cancer Battle" expands its focus to a global perspective, addressing the disparities in access to these life-saving treatments. It looks at the efforts being made to bridge the gap, ensuring that advancements in cancer care reach every corner of the world. Whether you are a medical professional, researcher, or someone affected by cancer, this book is an invaluable resource that not only informs but inspires. With its comprehensive coverage and forward-looking insights, "Immunotherapy Cancer Battle: Innovative Approaches for Success" is more than just a book—it's a blueprint for the future of cancer treatment. Join us in exploring these pioneering frontiers and envision a world where cancer is no longer a death sentence but a disease we can outsmart, treat, and one day, perhaps, completely eradicate.
Author: Jasmine Johnson Publisher: Murphy & Moore Publishing ISBN: 9781639870165 Category : Health & Fitness Languages : en Pages : 240
Book Description
The stimulation of the immune system through artificial means for the treatment of cancer is known as cancer immunotherapy. It boosts the ability of the immune system to fight cancer cells. It is a subspecialty within oncology. The antibody proteins belonging to the immune system are able to detect the tumor antigens and bind with them. Immunotherapy can be broadly divided into two types, namely, passive immunotherapy and active immunotherapy. The tumor cells are specifically targeted through the immune system in active immunotherapy. Within passive immunotherapy, the cancer cells are not directly attacked by the immunotherapy, but the ability of the immune system to attack cancer cells is enhanced. This book includes some of the vital pieces of work being conducted across the world, on various topics related to cancer immunotherapy. Also included herein is a detailed explanation of the various concepts and applications of this branch of therapy. This book includes contributions of experts and scientists which will provide innovative insights into this field.
Author: Ari VanderWalde Publisher: ISBN: 9783036528205 Category : Languages : en Pages : 174
Book Description
Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
Author: Priya Hays Publisher: Springer Nature ISBN: 3030801004 Category : Medical Languages : en Pages : 755
Book Description
This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients.
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309679060 Category : Medical Languages : en Pages : 83
Book Description
The National Academies of Sciences, Engineering, and Medicine held the workshop Applying Big Data to Address the Social Determinants of Health in Oncology on October 28â€"29, 2019, in Washington, DC. This workshop examined social determinants of health (SDOH) in the context of cancer, and considered opportunities to effectively leverage big data to improve health equity and reduce disparities. The workshop featured presentations and discussion by experts in technology, oncology, and SDOH, as well as representatives from government, industry, academia, and health care systems. This publication summarizes the presentations and discussions from the workshop.
Author: Keith Block Publisher: Bantam ISBN: 0553801147 Category : Health & Fitness Languages : en Pages : 610
Book Description
Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.
Author: Steven Johnson Publisher: Portal Books ISBN: 9781938685354 Category : Medical Languages : en Pages : 0
Book Description
Human disease is an elaborate dance between behavior, our environment, and chance. Medicine tries to tame human disease with science, but when our knowledge falls short, disease wins. This is too often the case with cancer. We spend billions of dollars each year trying to better understand it and develop tools to ease its effects. Today, many allopathic medical practitioners are beginning to seek out a greater connection with holistic and integrative approaches. The authors of this book introduce one specific therapy and make a case for integrative health in general, including anthroposophically extended medicine, naturopathy, and other holistic approaches. Mistletoe therapy has long been considered a viable treatment for cancer by the European medical community and is beginning to gain recognition in North America, as well. The mistletoe plant possesses many remarkable properties. As a therapy, it represents a rediscovery of ancient wisdom and shows us how the science of modern medicine might expand its reach and reconnect with a more human-centered medicine. The book was structured following the syllabus for a three-day practitioner training hosted by the Physicians' Association for Anthroposophic Medicine (PAAM). The chapters highlight several of our key lectures in a condensed form. The book serves as an introductory summary of--not a replacement for--those intensive professional trainings. This book is constructed as a journey and is meant to be read in its entirety, whether by a patient, a practitioner, a supporter of integrative oncology, or anyone who takes a deep interest in one's own health concerns. The text is accessible, and the reader does not need a science background to understand the majority of the content. While this book should not be considered a treatment or diagnostic manual, it is intended to both prepare practitioners to begin mistletoe therapy training and to make this information available in an accessible form to anyone interested in learning about this approach to treating cancer. Illustrated in color and b/w
Author: PATHAN AZHER KHAN
Author: PATHAN AZHER KHAN
Author: National Academies of Sciences, Engineering, and Medicine
Author: Azhar ul Haque Sario
Author: Jasmine Johnson
Author: Lisa H. Butterfield
Author: Ari VanderWalde
Author: Priya Hays
Author: National Academies of Sciences, Engineering, and Medicine
Author: Keith Block
Author: Steven Johnson