Advanced PH Control and Measurement in Bioreactors PDF Download

Author: Neeraj Gokhale
Publisher:
ISBN:
Category :
Languages : en
Pages : 146

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Author: Gregory K. McMillan
Publisher: ISA
ISBN: 9781934394434
Category : Science
Languages : en
Pages : 314

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Book Description

Author: Mojtaba Aghajani Delavar
Publisher: Academic Press
ISBN: 0323903746
Category : Medical
Languages : en
Pages : 266

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Book Description
Advanced Mathematical Modelling of Biofilms and its Applications covers the concepts and fundamentals of biofilms, including sections on numerical discrete and numerical continuum models and different biofilms methods, e.g., the lattice Boltzmann method (LBM) and cellular automata (CA) and integrated LBM and individual-based model (iBM). Other sections focus on design, problem-solving and state-of-the-art modelling methods. Addressing the needs to upgrade and update information and knowledge for students, researchers and engineers on biofilms in health care, medicine, food, aquaculture and industry, this book also covers areas of uncertainty and future needs for advancing the use of biofilm models. Over the past 25-30 years, there have been rapid advances in various areas of computer technologies, applications and methods (e.g. complex programming and algorithms, lattice Boltzmann method, high resolution visualization and high-performance computation). These new and emerging technologies are providing unprecedented opportunities to develop modeling frameworks of biofilms and their applications. Introduces state-of-the-art methods of biofilm modeling, such as integrated lattice Boltzmann method (LBM) and cellular automata (CA) and integrated LBM and individual-based model (iBM) Provides recent progress in more powerful tools for a deeper understanding of biofilm complexity by implementing state-of-the art biofilm modeling programs Compares advantages and disadvantages of different biofilm models and analyzes some specific problems for model selection Evaluates novel process designs without the cost, time and risk of building a physical prototype of the process to identify the most promising designs for experimental testing

Author: Carl-Fredrik Mandenius
Publisher: John Wiley & Sons
ISBN: 3527683372
Category : Science
Languages : en
Pages : 520

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Book Description
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Author: Carl-Fredrik Mandenius
Publisher: Springer
ISBN: 3642368387
Category : Science
Languages : en
Pages : 288

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Book Description
Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy, by Bernhard Sonnleitner Automatic Control of Bioprocesses, by Marc Stanke, Bernd Hitzmann An Advanced Monitoring Platform for Rational Design of Recombinant Processes, by G. Striedner, K. Bayer Modelling Approaches for Bio-Manufacturing Operations, by Sunil Chhatre Extreme Scale-Down Approaches for Rapid Chromatography Column Design and Scale-Up During Bioprocess Development, by Sunil Chhatre Applying Mechanistic Models in Bioprocess Development, by Rita Lencastre Fernandes, Vijaya Krishna Bodla, Magnus Carlquist, Anna-Lena Heins, Anna Eliasson Lantz, Gürkan Sin and Krist V. Gernaey Multivariate Data Analysis for Advancing the Interpretation of Bioprocess Measurement and Monitoring Data, by Jarka Glassey Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks, by Inês A. Isidro, Ana R. Ferreira, João J. Clemente, António E. Cunha, João M. L. Dias, Rui Oliveira Knowledge Management and Process Monitoring of Pharmaceutical Processes in the Quality by Design Paradigm, by Anurag S Rathore, Anshuman Bansal, Jaspinder Hans The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses, by Ian Marison, Siobhán Hennessy, Róisín Foley, Moira Schuler, Senthilkumar Sivaprakasam, Brian Freeland

Author: Gregory K. McMillan
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 320

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Book Description
This book has been revised to reflect developments in pH control. It instructs on the use of graphical and algebraic techniques for system analysis and signal characterization. Examples show potential pitfalls and ensure successful system design and implementation. The text discusses the factors that make pH loops so difficult to control.

Author: G. Bastin
Publisher: Elsevier
ISBN: 1483290980
Category : Technology & Engineering
Languages : en
Pages : 394

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Book Description
This book deals with monitoring and control of biotechnological processes. Different methods are proposed which are based on the nonlinear structure of the process and do not require any a priori knowledge of the fermentation parameters. The theoretical stability and convergence properties of the proposed algorithms are analysed and their performances are illustrated by simulation results and, in many instances, by real life experiments. The concept of software sensors is introduced; these are algorithms based on the nonlinear model of the process and designed for on-line estimation of the biological variables and/or the fermentation parameters. In order to deal with process nonstationarities and parameter uncertainties, reference is made to adaptive estimation and control techniques.The book is the result of an intensive joint research effort by the authors during the last decade. It is intended as a graduate level text for students of bioengineering as well as a reference text for scientists and engineers involved in the design and optimization of bioprocesses.

Author: Michael A. Boudreau
Publisher: ISA
ISBN: 9781556179051
Category : Science
Languages : en
Pages : 356

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Book Description
Models offer benefits even before they are put on line. Based on years of experience, the authors reveal in New Directions in Bioprocess Modeling and Control that significant improvements can result from the process knowledge and insight that are gained when building experimental and first-principle models for process monitoring and control. Doing modeling in the process development and early commercialization phases is advantageous because it increases process efficiency and provides ongoing opportunities for improving process control. This technology is important for maximizing benefits from analyzers and control tool investments. If you are a process design, quality control, information systems, or automation engineer in the biopharmaceutical, brewing, or bio-fuel industry, this handy resource will help you define, develop, and apply a virtual plant, model predictive control, first-principle models, neural networks, and multivariate statistical process control. The synergistic knowledge discovery on bench top or pilot plant scale can be ported to industrial scale processes. This learning process is consistent with the intent in the Process Analyzer and Process Control Tools sections of the FDA_s Guidance for Industry PAT _ A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance. It states in the Process Analyzer section of the FDA_s guidance: _For certain applications, sensor-based measurements can provide a useful process signature that may be related to the underlying process steps or transformations. Based on the level of process understanding these signatures may also be useful for the process monitoring, control, and end point determination when these patterns or signatures relate to product and process quality._

Author: Aaron Alexander Griswold
Publisher:
ISBN:
Category :
Languages : en
Pages : 36

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Book Description
A miniaturized bioreactor with a volume on the order of 100 [micro]l has been built with the aim of increasing the efficiency of the screening process for various microbial cultures. Unlike larger reactors currently in use, the current miniaturized design lacks a method of pH control. Without pH control, cell growth can be hindered or even stopped altogether when the growing medium becomes too acidic. Using technology already in place to optically measure the pH inside the reactor in conjunction with a valve and a base-filled reservoir, a simple closed-loop (feedback) control system has been developed. The volume of base injected into the reactor must be minimized because the reactor itself is so small. Data is recorded and control signals are outputted by a computer running LabView software. While the control system developed in this thesis shows promise, further development is needed before it can be put to good use.

Author: Elena Zattoni
Publisher: Springer Nature
ISBN: 3030853187
Category : Technology & Engineering
Languages : en
Pages : 1441

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Book Description
This book, published in two volumes, embodies the proceedings of the 15th European Workshop on Advanced Control and Diagnosis (ACD 2019) held in Bologna, Italy, in November 2019. It features contributed and invited papers from academics and professionals specializing in an important aspect of control and automation. The book discusses current theoretical research developments and open problems and illustrates practical applications and industrial priorities. With a focus on both theory and applications, it spans a wide variety of up-to-date topics in the field of systems and control, including robust control, adaptive control, fault-tolerant control, control reconfiguration, and model-based diagnosis of linear, nonlinear and hybrid systems. As the subject coverage has expanded to include cyber-physical production systems, industrial internet of things and sustainability issues, some contributions are of an interdisciplinary nature, involving ICT disciplines and environmental sciences. This book is a valuable reference for both academics and professionals in the area of systems and control, with a focus on advanced control, automation, fault diagnosis and condition monitoring.