Breast Cancer Metastasis and Drug Resistance PDF Download

Author: Aamir Ahmad
Publisher: Springer Nature
ISBN: 3030203018
Category : Medical
Languages : en
Pages : 432

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Book Description
Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Author: Manfred Schwab
Publisher: Springer Science & Business Media
ISBN: 3540368477
Category : Medical
Languages : en
Pages : 3307

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Book Description
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Author: Andrea Lenzi
Publisher: Springer
ISBN: 3319090453
Category : Medical
Languages : en
Pages : 346

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Book Description
This book describes in detail the multidisciplinary management of obesity, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical exercise, psychological issues, nutritional strategies, pharmacological options and bariatric surgery. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of obesity, which has rapidly become a major public health problem.

Author: Alexander Pfeifer
Publisher: Springer
ISBN: 303010513X
Category : Science
Languages : en
Pages : 418

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Book Description
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.

Author: Alexander Birbrair
Publisher: Springer Nature
ISBN: 3030362140
Category : Science
Languages : en
Pages : 155

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Book Description
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Author: John R. Goldblum
Publisher: Elsevier Health Sciences
ISBN: 1455737631
Category : Medical
Languages : en
Pages : 1173

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Book Description
Enzinger and Weiss's Soft Tissue Tumors is your essential medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. No other source matches Enzinger and Weiss’s scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compare what you see under the microscope to nearly 2,000 superb images that capture the appearance of a complete range of pathological entities and help you relate their characteristics to their specific classifications. Apply the latest knowledge on FNA biopsy, molecular biology, and cytogenetics. Make rapid and effective decisions with the aid of extensive algorithms, and access information at a glance with abundant tables and graphs. Take advantage of all of the essential clinical and prognostic data on soft tissue tumors that are necessary to formulate complete sign-out reports. Navigate through the book quickly thanks to summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.

Author: Tobias Pischon
Publisher: Springer
ISBN: 3319425420
Category : Medical
Languages : en
Pages : 258

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Book Description
This book provides a comprehensive and up-to-date review of the relationship between obesity and cancer. It opens with a global perspective on obesity and cancer incidence, followed by in-depth discussions of those cancers for which we have sufficient evidence of a causal relationship with obesity. It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adolescent obesity, and the role of body fat distribution in cancer risk. Individual chapters discuss potential pathways for the observed associations and explore possible mechanisms from both an epidemiological and an experimental perspective. It concludes with a population perspective on the cancer risk that is attributable to obesity and is thus potentially avoidable. This book is of particular value to researchers and epidemiologists and is also of interest to public health workers and clinicians.

Author: Elda Tagliabue
Publisher: MDPI
ISBN: 3036506926
Category : Medical
Languages : en
Pages : 120

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Book Description
Although cancer development and progression depend on stochastic mutational events, the tumor has to be seen in the context of the host environment, and unraveling the environmental factors that support solid tumors is at the root of cancer prevention and cure. This Special Issue, focused on the dynamic crosstalk that occurs between tumor cells and the surrounding microenvironment and also including the cancer cells that represent a reservoir of self-sustaining cells for tumor maintenance, adds new knowledge about tumor–host interactions that is useful for novel diagnostic and therapeutic approaches.

Author: Todd Leff
Publisher: John Wiley & Sons
ISBN: 9783527629534
Category : Science
Languages : en
Pages : 530

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Book Description
This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

Author: Kerry S. Courneya
Publisher: Springer Science & Business Media
ISBN: 3642042317
Category : Medical
Languages : en
Pages : 389

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Book Description
This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors are discussed, and behavior change strategies for increasing physical activity in cancer survivors are appraised. The final part of the book is devoted to special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.