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Author: Yunfeng Lin Publisher: Nova Science Publishers ISBN: 9781628087505 Category : Adipose tissues Languages : en Pages : 0
Book Description
Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. Adipogenesis has been one of the most intensively studied models of cellular differentiation. The exact mechanisms of adipogenesis remain unclear, since it involves abundant gene, growth factors, cytokines and environmental factors. This book provides an in-depth overview of current knowledge about the subject of adipogenesis in the human body, including what is known about molecular mechanisms (eg: cytokine- and growth-factor-related). Transcriptional regulators control the expression of target genes by the interaction with cofactors, coactivators, chromatin remodelling complexes and also with general transcriptional machinery. Current data suggests that adipogenesis is regulated by complex signalling pathway interactions involving multiple transcription factors. Many signaling pathways follow an inverse relationship between osteogenic and adipogenic differentiation. To provide better insight into the basic mechanisms of MSC fate determination, it is crucial to understand the various signalling pathways and cytokine interactions that co-ordinate this process. Further elucidation of this dichotomy may both improve understanding of human disease and speed the realisation of MSC mediated tissue engineering. There are a number of gaps in current knowledge of how adipogenesis actually occurs, and the authors are hopeful that the publication of this book will help researchers in this field to decide where to focus their future efforts. Contributions are therefore sought from anyone who is undertaking research in this area. The book will also provide an overview for surgeons and clinicians who wish to be kept abreast of developments in this fascinating subject.
Author: Joana Vieira Silva Publisher: Springer Nature ISBN: 3030444368 Category : Medical Languages : en Pages : 444
Book Description
Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Yunfeng Lin Publisher: Nova Science Publishers ISBN: 9781628087505 Category : Adipose tissues Languages : en Pages : 0
Book Description
Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. Adipogenesis has been one of the most intensively studied models of cellular differentiation. The exact mechanisms of adipogenesis remain unclear, since it involves abundant gene, growth factors, cytokines and environmental factors. This book provides an in-depth overview of current knowledge about the subject of adipogenesis in the human body, including what is known about molecular mechanisms (eg: cytokine- and growth-factor-related). Transcriptional regulators control the expression of target genes by the interaction with cofactors, coactivators, chromatin remodelling complexes and also with general transcriptional machinery. Current data suggests that adipogenesis is regulated by complex signalling pathway interactions involving multiple transcription factors. Many signaling pathways follow an inverse relationship between osteogenic and adipogenic differentiation. To provide better insight into the basic mechanisms of MSC fate determination, it is crucial to understand the various signalling pathways and cytokine interactions that co-ordinate this process. Further elucidation of this dichotomy may both improve understanding of human disease and speed the realisation of MSC mediated tissue engineering. There are a number of gaps in current knowledge of how adipogenesis actually occurs, and the authors are hopeful that the publication of this book will help researchers in this field to decide where to focus their future efforts. Contributions are therefore sought from anyone who is undertaking research in this area. The book will also provide an overview for surgeons and clinicians who wish to be kept abreast of developments in this fascinating subject.
Author: Maria Foti Publisher: Academic Press ISBN: 0128042192 Category : Medical Languages : en Pages : 305
Book Description
Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types. Categorizes the cytokines based primarily on tissue and target cells Emphasizes different roles and outcomes observed during innate and adaptive response Represents a rapid guide to cytokines in health and disease in tissue and organ context Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells
Author: Yunfeng Lin Publisher: ISBN: 9781628087536 Category : Science Languages : en Pages : 208
Book Description
Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. Adipogenesis has been one of the most intensively studied models of cellular differentiation. The exact mechanisms of adipogenesis remain unclear, since it involves abundant gene, growth factors, cytokines and environmental factors. This book provides an in-depth overview of current knowledge about the subject of adipogenesis in the human body, including what is known about molecular mechanisms (e.g. cytokine- and growth-factor-related). Transcriptional regulators control the expression of target genes by the interaction with cofactors, coactivators, chromatin remodelling complexes and also with general transcriptional machinery. Current data suggests that adipogenesis is regulated by complex signaling pathway interactions involving multiple transcription factors. Many signaling pathways follow an inverse relationship between osteogenic and adipogenic differentiation. To provide better insight into the basic mechanisms of MSC fate determination, it is crucial to understand the various signaling pathways and cytokine interactions that coordinate this process. Further elucidation of this dichotomy may both improve understanding of human disease and speed the realization of MSC mediated tissue engineering. There are a number of gaps in current knowledge of how adipogenesis actually occurs, and the authors are hopeful that the publication of this book will help researchers in this field to decide where to focus their future efforts. Contributions are therefore sought from anyone who is undertaking research in this area. The book will also provide an overview for surgeons and clinicians who wish to be kept abreast of developments in this fascinating subject.
Author: Alexander Pfeifer Publisher: Springer ISBN: 303010513X Category : Science Languages : en Pages : 424
Book Description
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Author: Jean-Philippe Bastard Publisher: Springer Science & Business Media ISBN: 2817803434 Category : Medical Languages : en Pages : 432
Book Description
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
Author: Yihai Cao Publisher: Springer Science & Business Media ISBN: 1461480698 Category : Medical Languages : en Pages : 374
Book Description
Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..
Author: Yunfeng Lin
Author: Jennifer Arianne Kennell
Author: Joana Vieira Silva
Author: Yunfeng Lin
Author: Maria Foti
Author: Yunfeng Lin
Author: Robin Leigh Erickson
Author: Alexander Pfeifer
Author: Sarah Rebecca Hummasti
Author: Jean-Philippe Bastard
Author: Yihai Cao