Author: Felix Z. Meerson Publisher: CRC Press ISBN: 100069674X Category : Medical Languages : en Pages : 308
Book Description
Published in 1991: This book explores the possibilities of protecting the heart against stress and ischemia through adaptation to intermittent hypoxia or to mild, nondamaging stress exposure. These possibilities are based on studies that show an increase in the potency and efficiency of stress-limiting systems when subjected to repeated stress actions, adaptation to high altitude hypoxia, or adaptation to increased physical loads. Any stress reaction is coupled with an activation of central and local stress-limiting systems, such as GABA-ergic, opioidergic, and serotonergic systems in the brain, as well as antioxidants, prostaglandins, and adenosine in executory organs. The book also presents the use of metabolites of stress-limiting systems rather than adaptation as a means to prevent cardiac arrythmias. It also discusses genetically determined deficiencies of stress-limiting systems and their role in the etiology of stress-induced diseases. Cardiologists and researchers studying stress and its effect on cardiovascular systems will find this book extremely useful.
Author: A.R Hargens Publisher: ALPHA SCIENCE INTERNATIONAL LIMITED ISBN: 8184872895 Category : Medical Languages : en Pages : 357
Book Description
Recognition of adaptive processes in biological systems as a discipline is still in its infancy. It is known that repeat exposure to low level stresses such as heat, cold, microgravity, hypoxia, exercise, etc. increases body-resistance to not only the particular stress but also to other conditions. Such a cross-protection can be utilized in a better patient care. This volume describes most current developments in the understanding of the molecular basis of adaptation as well as its application in biological systems including certain disease conditions in humans. The book is based on the presentations made by internationally known experts assembled in San Diego, USA for the 7th World Congress of the International Society for Adaptive Medicine and will be of great interest to experimental biologists as well as clinicians who deal with a wide variety of clinical conditions.
Author: Malcolm J Lewis Publisher: CRC Press ISBN: 1000725340 Category : Medical Languages : en Pages : 272
Book Description
Paracrine and autocrine regulation of cardiac function by "endothelial" mediators is becoming important both physiologically and pathophysiologically. This volume brings the researcher completely up to date with all aspects of endothelial regulation and cardiac function. Acknowledged experts in each field have contributed, making this work indispensable for researchers and of great interest to the clinical cardiologist. The Endothelial Cell Research Series publishes significant reviews by experts in the field. The individual volumes provide invaluable guides to researchers studying endothelial cells and are effective reference texts for anyone working in the general areas of vascular biology and neurotransmission. Endothelium was originally considered to be an inert lining for the blood vessels, but during the last fifteen years, this view has had to be completely revised. It is now accepted that the endothelium plays an important role in many diverse functions. This volume concentrates on the effect of the endothelium on cardiac function. It has been widely demonstrated that the endothelium exerts a paracrine influence on contraction of adjacent cardiac muscle through the release of several mediators, such as endothelin and nitric oxide. Recent studies also show that the effects of such mediators upon the heart are not limited to contraction alone.
Author: Stefan O. Reber Publisher: Frontiers Media SA ISBN: 2889450848 Category : Languages : en Pages : 131
Book Description
Chronic or repeated stress, particularly psychosocial stress, is an acknowledged risk factor for numerous affective and somatic disorders in modern societies. Thus, there is substantial evidence showing that chronic stress can increase the likelihood of major depressive disorder and anxiety disorders, as well as cardiovascular diseases, irritable bowel syndrome and pain syndromes, to name but a few, in vulnerable individuals. Although a number of pharmacological agents are available to treat such stress-related disorders, many patients do not respond to them, and those who do often report a number of side effects. Therefore, a major emphasis in modern basic research is to uncover the underlying aetiology of these disorders, and to develop novel efficacious treatment strategies. This has led to a resurgence in developing, and using, appropriate animal models to study a wide variety of stress-related disorders. Thus, the aim of this research topic “Using stress-based animal models to understand the mechanisms underlying psychiatric and somatic disorders” was to bring together novel research articles and comprehensive review articles from prominent stress researchers. In addition to describing the insights such models have provided relating to the aetiology of psychiatric and somatic disorders, these articles also encompass mechanisms that are believed to underlie stress resilience and stress-protection. Finally, given the current prominence on the role of the brain-gut axis in health and disease, the research topic covers the emerging evidence showing how the gut, particularly the microbiota, influences affective behaviour and physiology.
Author: FELIX Z. MEERSON Publisher: CRC Press ISBN: 9780367246259 Category : Languages : en Pages : 312
Book Description
Published in 1991: This book explores the possibilities of protecting the heart against stress and ischemia through adaptation to intermittent hypoxia or to mild, nondamaging stress exposure. These possibilities are based on studies that show an increase in the potency and efficiency of stress-limiting systems when subjected to repeated stress actions, adaptation to high altitude hypoxia, or adaptation to increased physical loads. Any stress reaction is coupled with an activation of central and local stress-limiting systems, such as GABA-ergic, opioidergic, and serotonergic systems in the brain, as well as antioxidants, prostaglandins, and adenosine in executory organs. The book also presents the use of metabolites of stress-limiting systems rather than adaptation as a means to prevent cardiac arrythmias. It also discusses genetically determined deficiencies of stress-limiting systems and their role in the etiology of stress-induced diseases. Cardiologists and researchers studying stress and its effect on cardiovascular systems will find this book extremely useful.
Author: J.M. Storey Publisher: Elsevier ISBN: 0080531121 Category : Science Languages : en Pages : 325
Book Description
Cell and Molecular Responses to Stress is a new multi-volume book series from Elsevier Science that focuses on how organisms respond at a molecular level to environmental stresses imposed upon them. All organisms deal with variations in multiple environmental factors including temperature, oxygen, salinity, and water availability. Many show amazing tolerances to extreme stress with remarkable biochemical adaptations that allow life to persist under very difficult circumstances. This series explores the molecular mechanisms by which cells and organisms respond to stress, focusing on the variations in metabolic response that allow some cells and organisms to deal with extreme stress, others to endure stress within strict limits, and others to have a very low tolerance for changes in environmental parameters.Articles from within the series highlight the elastic limits of molecular responses in Nature, with examples drawn from animal, plant and bacteria systems.Volume 1, begins by considering some of the roles of environmental stress in determining the geographic distribution of animals and in promoting species divergence and then explores gene expression and metabolic responses to environmental stress with examples of adaptation to high and low temperature, osmotic, anoxia/ischemia, desiccation, high pressure and heavy metal stresses.
Author: S.K. Gupta Publisher: Springer Science & Business Media ISBN: 9780792370598 Category : Science Languages : en Pages : 772
Book Description
During the past several years tremendous advancements have been made in the field of pharmacology and therapeutics. While new therapeutic strategies are coming up, old ones are being improved by modifications, or being replaced with newer ones. The major topics covered in this book include: endothelins, current topics in cardiovascular research, molecular pharmacology, recent developments in cancer research, antioxidants, oxidants and human disease, herbal drugs, developments in neuropharmacology, myelin biology and demyelinating disease, pharmacovigilance, role of cytokines in health and disease, ocular pharmacology, detoxification of xenobiotics-biotransformation and transport, and several other topics of current interest. The aim of this book is to fulfill the needs of the basic and clinical researchers as well as the students, particularly related to areas of current interest in pharmacology and therapeutics.
Author: Felix Z. Meerson
Author: 
Author: A.R Hargens
Author: Alexander E. Kabakov
Author: Malcolm J Lewis
Author: Stefan O. Reber
Author: FELIX Z. MEERSON
Author: National Library of Medicine (U.S.)
Author: J.M. Storey
Author: S.K. Gupta