Activated Metals in Organic Synthesis PDF Download

Author: P. Cintas
Publisher: CRC Press
ISBN: 9780849378638
Category : Science
Languages : en
Pages : 250

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Book Description
Activated Metals in Organic Synthesis discusses fundamental principles of the generation of activated, highly reactive metals, and their applications in organic synthesis. Following an introductory chapter on basic forms of metals the chapters in Part 1 are devoted to common strategies utilized for the preparation of active metals. These strategies include vaporization and subsequent co-condensation of metal atoms, in addition to depassivating methods employed commonly in laboratory syntheses. Chapters in Part 2 discuss relevant organic transformations in which metal activation plays a crucial role. Specific topics covered include metal-induced reductive methods; pinacolic, Reformatsky-, and Barbier-type reactions; McMurry ketone-olefin coupling; and the Bernet-Vasella reaction. Each chapter is followed by literature citations ranging from specific references to significant reviews. Many structural formulas are provided, making it easy to follow each synthesis. The book will be an important reference for students, organic chemists, and researchers in all areas of organometallic chemistry.

Author: Alois Fürstner
Publisher: John Wiley & Sons
ISBN: 3527615164
Category : Science
Languages : de
Pages : 482

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Book Description
Reactions with metals are ubiquitous in organic synthesis and, particularly in the last few years, a large repertoire of methods for the activation of metals and for their use in organic synthesis has been developed. In Active Metals, topics ranging from morphology of metal clusters and nanometallurgy to organometallic chemistry, catalysis and the use of activated metals in natural product synthesis are authoritatively discussed by leading experts in the field. Active Metals will allow you to fully benefit from the recent advances in the field by giving: * Detailed experimental procedures * Guidance on manipulation of active metals under inert atmosphere * Valuable information for planning syntheses * Extensive tables of typical conversions with yields * Critically selected, up-to-date references This handbook is a unique source of 'hands-on' information which will allow you to expand the scope of your research.

Author: P. Cintas
Publisher: CRC Press
ISBN: 1000714772
Category : Science
Languages : en
Pages : 247

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Book Description
Activated Metals in Organic Synthesis discusses fundamental principles of the generation of activated, highly reactive metals, and their applications in organic synthesis. Following an introductory chapter on basic forms of metals the chapters in Part 1 are devoted to common strategies utilized for the preparation of active metals. These strategies include vaporization and subsequent co-condensation of metal atoms, in addition to depassivating methods employed commonly in laboratory syntheses. Chapters in Part 2 discuss relevant organic transformations in which metal activation plays a crucial role. Specific topics covered include metal-induced reductive methods; pinacolic, Reformatsky-, and Barbier-type reactions; McMurry ketone-olefin coupling; and the Bernet-Vasella reaction. Each chapter is followed by literature citations ranging from specific references to significant reviews. Many structural formulas are provided, making it easy to follow each synthesis. The book will be an important reference for students, organic chemists, and researchers in all areas of organometallic chemistry.

Author: Boris I. Kharisov
Publisher: CRC Press
ISBN: 1439853436
Category : Science
Languages : en
Pages : 867

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Book Description
As nanotechnology has developed over the last two decades, some nanostructures, such as nanotubes, nanowires, and nanoparticles, have become very popular. However, recent research has led to the discovery of other, less-common nanoforms, which often serve as building blocks for more complex structures. In an effort to organize the field, the Handbook of Less-Common Nanostructures presents an informal classification based mainly on the less-common nanostructures. A small nanotechnological encyclopedia, this book: Describes a range of little-known nanostructures Offers a unifying vision of the synthesis of nanostructures and the generalization of rare nanoforms Includes a CD-ROM with color versions of more than 100 nanostructures Explores the fabrication of rare nanostructures, including modern physical, chemical, and biological synthesis techniques The Handbook of Less-Common Nanostructures discusses a classification system not directly related to the dimensionality and chemical composition of nanostructure-forming compounds or composite. Instead, it is based mainly on the less-common nanostructures. Possessing unusual shapes and high surface areas, these structures are potentially very useful for catalytic, medical, electronic, and many other applications.

Author: B.I. Kharisov
Publisher: Elsevier
ISBN: 0128110627
Category : Science
Languages : en
Pages : 470

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Book Description
Direct Synthesis of Metal Complexes provides in-depth coverage of the direct synthesis of coordination and organometallic compounds. The work is primarily organized by methods, but also covers highly relevant complexes, such as metal-polymer coordination compounds. This updated reference discusses recent developments in cryosynthesis, electrosynthesis, and tribosynthesis (popular as it doesn't require organic solvents), with special attention paid to 'greener' methodologies and approaches. Additionally, the book describes physical methods of zero-valent metal interaction with organic matter, including sputtering, ultrasonic treatment and synthesis in ionic liquids. The book presents completely new content as a follow-up to the 1999 Elsevier Science publication Direct Synthesis of Coordination and Organometallic Compounds that was edited by Dr. Garnovskii and Dr. Kharisov. - Covers current methods and techniques of metal interactions with organic media leading to metal chelates, adducts, di- and polymetallic complexes, metal-containing macrocycles, supported coordination compounds (i.e., metal complexes on carbon nanotubes), and more - Describes reactivities of distinct forms of elemental metals (powders, sheets, nanoparticles (including a host of less-common metal nanostructures) with organic phase (liquid, solid and gaseous) and water - Includes experimental procedures, with examples of direct synthesis, at the end of each chapter

Author: Jean-Louis Luche
Publisher: Springer Science & Business Media
ISBN: 1489919104
Category : Science
Languages : en
Pages : 447

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Book Description
TEAN-LOUIS LUCHE A French poet of this eentury, Pierre Mae Orlan, wrote "Adventure does not exist, it is only in the mind of he who is pursuing it, and, as soon as it is at one's finger tips, it vanishes to come back to life, far away, in a different shape, at the frontiers of imagination". This sentence could be used to define the adventure that many sonochemists experienced. Most of them did not even suspect that the "laboratory trick" they were using was the first contact with a considerable amount of science. If a personal note is allowed here, it ean be interesting to mention the part played by chance in my involvement in sonochemistry. Almost 20 years ago, we had to perform an apparently simple Grignard reaetion with n-butylmagnesium bromide and geranial, but the results were repeatedly unsatisfactory. The one-pot Barbier technique was attempted, also without success. From my studies at the University, I imagined that the failure of the latter reaction could be caused by a common phenomenon known by solid state chemists as passivation, which in some cases can be overcome by ultrasonication. By chance, an ultrasonie bath was sitting on the next beneh, borrowed to clean some equipment. We clamped our reluctant reaction mixture into the bath, the reaction proceeded vigorously, and ... the adventure started. Without knowing anything about cavitation, high energies, ete., we had an illustration of Goethe's word "Am Anfang war die Tat" (at the Beginning was the Act).

Author: Thomas J. Colacot
Publisher: John Wiley & Sons
ISBN: 3527345175
Category : Science
Languages : en
Pages : 336

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Book Description
Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Author: Ender Erdik
Publisher: CRC Press
ISBN: 1000108562
Category : Science
Languages : en
Pages : 432

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Book Description
Organozinc reagents are used extensively in organic synthesis to find useful pathways to organic products. Illustrated and tabulated with over 950 equations, schemes, tables, and figures, Organozinc Reagents in Organic Synthesis provides an overall picture of the chemistry of organozinc compounds. Written by a professor of organic chemistry, the book familiarizes the reader with the reactions involving organozinc reagents that have general usefulness in synthesis. Emphasis is placed on preparation methods and reactivity of organozinc reagents. Reactions are summarized in equations and schemes, making it easy for you to see the characteristics of each type of reaction.

Author: Laszlo Kurti
Publisher: Elsevier
ISBN: 0080575412
Category : Science
Languages : en
Pages : 808

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Book Description
Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. - The first reference work on named reactions to present colored schemes for easier understanding - 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples - An opening list of abbreviations includes both structures and chemical names - Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works - Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools - Extensive index quickly locates information using words found in text and drawings

Author: Roderick Bates
Publisher: John Wiley & Sons
ISBN: 1119978947
Category : Science
Languages : en
Pages : 469

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Book Description
Transition metals open up new opportunities for synthesis, because their means of bonding and their reaction mechanisms differ from those of the elements of the s and p blocks. In the last two decades the subject has mushroomed - established reactions are seeing both technical improvements and increasing numbers of applications, and new reactions are being developed. The practicality of the subject is demonstrated by the large number of publications coming from the process development laboratories of pharmaceutical companies, and its importance is underlined by the fact that three Nobel prizes have been awarded for discoveries in this field in the 21st Century already. Organic Synthesis Using Transition Metals, 2nd Edition considers the ways in which transition metals, as catalysts and reagents, can be used in organic synthesis, both for pharmaceutical compounds and for natural products. It concentrates on the bond-forming reactions that set transition metal chemistry apart from "classical" organic chemistry. Each chapter is extensively referenced and provides a convenient point of entry to the research literature. Topics covered include: introduction to transition metals in organic synthesis coupling reactions C-H activation carbonylative coupling reactions alkene and alkyne insertion reactions electrophilic alkene and alkyne complexes reactions of alkyne complexes carbene complexes h3- or p-allyl -allyl complexes diene, dienyl and arene complexes cycloaddition and cycloisomerisation reactions For this second edition the text has been extensively revised and expanded to reflect the significant improvements and advances in the field since the first edition, as well as the large number of new transition metal-catalysed processes that have come to prominence in the last 10 years – for example the extraordinary progress in coupling reactions using “designer” ligands, catalysis using gold complexes, new opportunities arising from metathesis chemistry, and C-H activation – without neglecting the well established chemistry of metals such as palladium. Organic Synthesis Using Transition Metals, 2nd Edition will find a place on the bookshelves of advanced undergraduates and postgraduates working in organic synthesis, catalysis, medicinal chemistry and drug discovery. It is also useful for practising researchers who want to refresh and enhance their knowledge of the field.