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Author: E. Ramon-Moliner Publisher: Springer Science & Business Media ISBN: 3642500552 Category : Medical Languages : en Pages : 53
Book Description
The earliest studies on the regional distribution of acetylcholinesterase (AChE) within the central nervous system were based on the determination of the amount of CO liberated by homogenates of selected areas in the presence of an ester of 2 choline and a bicarbonate buffer. Using this biochemical approach, Burgen and Chipman (1951) were able to establish that acetylcholinesterase is not evenly distributed within the central nervous system. They found that the cerebellum, the lateral geniculate body, and the striatum contained a high concentration of AChE. The high concentration of AChE in the striatum could be correlated with a higher rate of acetylcholine synthesis. However, this was not the case for the cerebellum, where acetylcholine synthesis was very low. Other in vitro studies have been aimed at establishing the regional distribution of the other two components of the cholinergic system, cholinacetylase (ChA) and acetylcholine (ACh). An equally asymetrical distribution for these substances has been established in vitro (MacIntosh, 1941 ; Feldberg and Mann, 1946; Feldberg and V ogt, 1948; MacIntosh and Oborin, 1953; Quastel, 1962; Mitchell, 1963; Krnjevic and Phillis, 1963; Aprison et al., 1964; McLennan, 1964; Cohen, 1956). The in vitro determination of acetylcholinesterase (Koelle, 1950; Burgen and Chipman, 1951; Giacobini, 1959; Bennett et al., 1966; Fahn and Cote, 1968; Miller et al., 1969) presents the advan tage of permitting the use of a substrate like ACh which is a normally occurring ester of choline so that the establishment of enzyme specificity is less questionable.
Author: E. Ramon-Moliner Publisher: Springer Science & Business Media ISBN: 3642500552 Category : Medical Languages : en Pages : 53
Book Description
The earliest studies on the regional distribution of acetylcholinesterase (AChE) within the central nervous system were based on the determination of the amount of CO liberated by homogenates of selected areas in the presence of an ester of 2 choline and a bicarbonate buffer. Using this biochemical approach, Burgen and Chipman (1951) were able to establish that acetylcholinesterase is not evenly distributed within the central nervous system. They found that the cerebellum, the lateral geniculate body, and the striatum contained a high concentration of AChE. The high concentration of AChE in the striatum could be correlated with a higher rate of acetylcholine synthesis. However, this was not the case for the cerebellum, where acetylcholine synthesis was very low. Other in vitro studies have been aimed at establishing the regional distribution of the other two components of the cholinergic system, cholinacetylase (ChA) and acetylcholine (ACh). An equally asymetrical distribution for these substances has been established in vitro (MacIntosh, 1941 ; Feldberg and Mann, 1946; Feldberg and V ogt, 1948; MacIntosh and Oborin, 1953; Quastel, 1962; Mitchell, 1963; Krnjevic and Phillis, 1963; Aprison et al., 1964; McLennan, 1964; Cohen, 1956). The in vitro determination of acetylcholinesterase (Koelle, 1950; Burgen and Chipman, 1951; Giacobini, 1959; Bennett et al., 1966; Fahn and Cote, 1968; Miller et al., 1969) presents the advan tage of permitting the use of a substrate like ACh which is a normally occurring ester of choline so that the establishment of enzyme specificity is less questionable.
Author: S Terashima Publisher: CRC Press ISBN: 1000159639 Category : Technology & Engineering Languages : en Pages : 218
Book Description
Since the early 1950s, work has been undertaken on the infrared sensory organs of snakes by a handful of investigators around the world. Despite progress in uncovering the morphological, physiological and behavioral functions of these organs, study was discontinued by most of these workers. Not the least of the reasons was the fact that the infrared organs are possessed either by highly venomous snakes, the pit vipers, or by equally dangerous snakes because of their size, the pythons and boas. Only Drs Shin-ichi Terashima, MD, Ph.D. and Richard C. Goris, Ph.D. have continued to work actively on these sensory organs, their work spanning the 30 years from 1967 to the present. A first collection of their works, Infrared Sensory System, was published by the university of the Ryukyus in 1987. The present volume presents the papers by Terashima, Goris and their colleagues from 1987 to the present. Much new light is shed on the physiology and morphology of these organs, which can truly be said to be infrared 'eyes' whose input is integrated with that from the eyes. This volume will be of considerable interest to all those interested in infrared detection of any kind, whether in nature or in its multifarious industrial applications.
Author: Rodolfo Llinas Publisher: Springer Science & Business Media ISBN: 1461228409 Category : Medical Languages : en Pages : 354
Book Description
This book is organized into three parts that correspond with the main groups of chapters delivered during the Cajal Centenary Meeting on The Neutron Doctrine. These chapters represent important aspects of the morphology, development, and function of the cerebellum and related structures. Clearly an exhaustive analysis of all aspects of the cerebellar system, as they relate to the legacy of Ramon y Cajal, would be impossible to contain in just one volume, given its far-reaching impact. Instead, we deliberately steered away from the traditional handbook approach that some of us have taken in the past and selected those aspects of cerebellar research currently under vigorous study that would also represent the widest scope of interest for neuroscientists in general and for cerebellar specialists in particular. In particular, we felt that as the discrete anatomy of the cerebellum is quite well known, only certain aspects of the structure should be discussed here. For example, the organization of the pontocerebellar pathways, we felt, would be particularly interesting given the enormity of the system in higher vertebrates. Also of interest is the distribution and development of the synaptology and neurotransmitter properties in this cortex. Indeed, from the point of view of cerebellar development, this may represent one of the clearest paradigms in the understanding of rules for neurogenesis for the central nervous system.
Author: Publisher: ISBN: Category : Medicine Languages : en Pages : 522
Book Description
Intended as annual listing of medical and paramedical books, cassette tapes, and films, currently available for the continuing education of physicians. Information provided by book publishers. Arranged by specialties. Entries include bibliographical data, Library of Congress number, price, and many annotations. Author index, list of pharmaceutical companies and addresses.
Author: E. Ramon-Moliner
Author: E. Ramon-Moliner
Author: E. Ramon-Moliner
Author: Enrique Ramon-Moliner
Author: S Terashima
Author: Rodolfo Llinas
Author: 
Author: 
Author: National Library of Medicine (U.S.)
Author: National Library of Medicine (U.S.)
Author: National Agricultural Library (U.S.)