Author: Jae H. ChangPublisher:
ISBN:
Category :
Languages : en
Pages : 456
Book Description
A Tale of Two Interplays: the Roles of the Interplay Between P-glycoprotein and UDP-glucuronosyltransferases and the Interplay Between Drug Efflux and Drug Influx Transporters in Drug Absorption
Author: Jae H. ChangAnti-inflammatory Nutraceuticals and Chronic Diseases
Author: Subash Chandra GuptaPublisher: Springer
ISBN: 3319413341
Category : Medical
Languages : en
Pages : 479
Book Description
This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.
Dissertation Abstracts International
Author: Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 794
Book Description
ADMET for Medicinal Chemists
Author: Katya TsaiounPublisher: John Wiley & Sons
ISBN: 0470922818
Category : Medical
Languages : en
Pages : 454
Book Description
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.
COSMO-RS
Author: Andreas KlamtPublisher: Elsevier
ISBN: 0080455530
Category : Technology & Engineering
Languages : en
Pages : 247
Book Description
The COSMO-RS technique is a novel method for predicting the thermodynamic properties of pure and mixed fluids which are important in many areas, ranging from chemical engineering to drug design. COSMO-RS, From Quantum Chemistry to Fluid Phase Thermodynamics and Drug Design is about this novel technology, which has recently proven to be the most reliable and efficient tool for the prediction of vapour-liquid equilibria. In contrast to group contribution methods, which depend on an extremely large number of experimental data, COSMO-RS calculates the thermodynamic data from molecular surface polarity distributions, resulting from quantum chemical calculations of the individual compounds in the mixture. In this book, the author cleverly combines a vivid overview of the partly demanding theoretical steps with a deeper analysis of their scientific background and justification. Aimed at theoretical chemists, computational chemists, physical chemists, chemical engineers, thermodynamicists as well as students,academic and industrial experts, COSMO-RS, From Quantum Chemistry to Fluid Phase Thermodynamics and Drug Design provides a novel viewpoint to anyone looking to gain more insight into the theory and potential of the unique method, COSMO-RS. - The only book currently available on COSMO-RS technique - Provides a novel viewpoint for the scientific understanding and for the practical quantitative treatment of fluid phase thermodynamics - Includes illustrative examples of the COSMOtherm program
Drug-Drug Interactions
Author: A. David RodriguesPublisher: CRC Press
ISBN: 0849375940
Category : Medical
Languages : en
Pages : 769
Book Description
Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes
Tocotrienols
Author: Ronald Ross WatsonPublisher: CRC Press
ISBN: 1420080393
Category : Medical
Languages : en
Pages : 424
Book Description
A New Avenue of Research Beyond Traditional Studies of Vitamin E In the current literature, more than 95% of all studies of vitamin E are directed toward the specific exploration of the bioactive component a-tocopherol. Until recently, there has been a dearth of research into non-tocopherol vitamin E molecules. A unique resource that examines the n
Molecular Design
Author: Gisbert SchneiderPublisher: John Wiley & Sons
ISBN: 9783527314324
Category : Science
Languages : en
Pages : 284
Book Description
Kleine Moleküle für Einsteiger: Dieser für Lehre und Selbststudium gleichermaßen geeignete Band behandelt den computergestützten Entwurf von Wirkstoffen, Enzyminhibitoren, Sonden und Markern für Biomoleküle und führt den Leser bis zum ersten eigenen De-Novo-Design eines funktionellen Moleküls. Gestützt auf lange Erfahrung im Molecular-Modeling-Umfeld erläutern die Autoren, welche Fragen mit den beschriebenen Methoden beantwortet werden können (und welche nicht).