A Survey of Compounds from the Antiradiation Drug Development Program of the U.S. Army Medical Research and Development Command PDF Download

Author: Thomas Richard Sweeney
Publisher:
ISBN:
Category : Drugs
Languages : en
Pages : 870

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Author: T. R. Sweeney
Publisher:
ISBN:
Category :
Languages : en
Pages : 849

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Female mice of the Walter Reed Bagg Swiss or Inbred Charles River (ICR) strains, 5-6 weeks old and weighing 21-25g, were randomly assigned to treatment groups. An estimation of the toxicity of each compound to be tested for antiradiation activity, i.e., a determination of the approximate LD50 (ALD 50), was obtained in separate experiments prior to irradiation. Toxicity estimations were based upon animal survival over a ten-day observation period following intraperitoneal or oral administration of each agent in graded doses using 10 mice at each dose level. Adverse symptomatology was noted and, in addition, each mouse was subjected to a post mortem examination. The highest dose of each compound administered for antiradiation testing was about two thirds of the ALD50 unless a lower dose was indicated by adverse symptomatology or pathologic changes; the selected doses of each compound were administered 15- 30 minutes before exposure to lethal whole body irradiation. Mortality was tabulated for a 30-day period for each individual animal and all data computerized. Under our conditions, approximately 800r x-ray and 1000r Co-60 gamma irradiation were equally lethal (LD-10030), all control animals dying between the tenth and twenty-first days following exposure.

Author: Thomas Richard Sweeney
Publisher:
ISBN:
Category : Radiation immunology
Languages : en
Pages : 0

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Author: John A. Kepler
Publisher:
ISBN:
Category :
Languages : en
Pages : 48

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This report summarizes work carried out on contract DAMD17-89-C-9062 during the period March 23, 1991 to March 22, 1992. The purpose of the work on this contract was to prepare and fully characterize radiolabeled samples of compounds which are of current interest to the U.S. Amy Medical Research and Development Command (USARMDC) and to provide these compounds along with some commercially prepared compounds to investigators designated by the USARMDC. The procedure followed for preparing the compounds involved first designing a synthetic scheme and then optimizing the individual reactions in the synthetic scheme using nonlabeled chemicals. When all of the reactions had been optimized, a tracer run was done where a small amount of the radiolabeled starting material was diluted with nonlabeled starting material, and the reaction sequence performed from beginning to end on the exact scale that was planned for the master run. Any problems which were discovered in the tracer run were worked out, and then the tracer run was repeated, if necessary, or the master run was done. The final products were analyzed for chemical and radiochemical purity, and specific activity. Procedures used for the analyses included TLC-radio-scan, autoradiography, HPLC, UV, and NMR and mass spectrometry where required. In addition to analyzing the compounds when they were first prepared, they were also analyzed prior to shipment to approved investigators. Antimalarial, carbon- 14, tritium, synthesis, radiolabel, chemical warfare protective agents RAD 5, 1.

Author: Ching Kuang Chow
Publisher: CRC Press
ISBN: 1000694232
Category : Medical
Languages : en
Pages : 259

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First Published in 1988, this three-volume set offers a full insight into the immune systems and its response to antioxidants. Carefully compiled and filled with diagrams, references and information this set is recommended for students of immunology and other professionals in their respective fields.

Author: Edward A. Bump
Publisher: CRC Press
ISBN: 1000103048
Category : Law
Languages : en
Pages : 446

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It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: Early research on radioprotectors WR-2721, an aminothiol prodrug, as a radioprotector New results with naturally occurring thiols Nitroxides as effective radioprotectors in vitro and in vivo Radioprotection observed with radical scavengers or antioxidants Bone marrow radioprotection with cytokines and biological modifiers Multiple mechanisms of altering radiation response by eicosanoids Vascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosis Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.

Author: Sang Hyun Cho
Publisher: Taylor & Francis
ISBN: 1439878765
Category : Medical
Languages : en
Pages : 281

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Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors-a

Author: Jules E. Harris
Publisher: CRC Press
ISBN: 9780849369032
Category : Medical
Languages : en
Pages : 266

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This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins.

Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
ISBN: 9815040774
Category : Medical
Languages : en
Pages : 248

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Frontiers in Natural Product Chemistry is a book series devoted to important advances in natural product chemistry. The series features volumes that cover all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume 10 of the series brings together 5 reviews on a variety of bioactive compounds. An overview of cistus species growing in Sardinia: a source of bioactive compounds Roles of natural abscisic acids in fruits during fruit development and under environmental stress Progress in the research of naturally occurring biflavonoids: a look through Plant metabolites for protecting human cells against radiation-associated damage: an integrative review Chemical perspective and drawbacks in flavonoid estimation assays

Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 664

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