Author: Karin Jane FeaseyPublisher:
ISBN:
Category :
Languages : en
Pages : 432
Book Description
A Study of Long-term Potentiation in the CA3 Region of the Hippocampus
Author: Karin Jane FeaseyA Study of Long-term Potentiation in the CA3 Region of the Rat Hippocampus
Author: Karin Jane FeaseySynaptic Plasticity in the Hippocampus
Author: Helmut L. HaasPublisher: Springer Science & Business Media
ISBN: 364273202X
Category : Medical
Languages : en
Pages : 219
Book Description
This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.
Long-term Potentiation
Author: M. BaudryPublisher: MIT Press
ISBN: 9780262023306
Category : Memory
Languages : en
Pages : 494
Book Description
Following the successful format of the first volume on long- term potentiation -- a leading candidate for the neuronal basis of learning and memory -- Volume 2 brings together the most recent data and hypotheses by top neuroscientists regarding the mechanisms of this phenomenon and of long-term depression (LTD). The book is divided into several sections covering different aspects of the field ranging from molecular mechanisms of plasticity to computational neurobiology. It revisits some of the major points covered in Volume 1, updating them in this fast-moving field. It also introduces several new issues that have arisen since then. Of the many possible new topics that could have been added, the editors have focused on retrograde messengers and the mechanisms and functions of LTP and LTD because they are the subject of much interest, research, and controversy. The section on retrograde messengers deals primarily with nitric oxide.
The Hippocampus Book
Author: Per AndersenPublisher: Oxford University Press
ISBN: 9780195100273
Category : Medical
Languages : en
Pages : 892
Book Description
The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
Neural Plasticity and Memory
Author: Federico Bermudez-RattoniPublisher: CRC Press
ISBN: 1420008412
Category : Psychology
Languages : en
Pages : 368
Book Description
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Long-term Potentiation
Author: Tim V. P. BlissPublisher:
ISBN: 9780198530305
Category : Medical
Languages : en
Pages : 440
Book Description
In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actual neural mechanism used by the brain to store information?This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.Advance praise for Long Term Potentiation: 'This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field.' Colin Blakemore, University of OxfordReadership: Neuroscientists from postgraduate level upwards
Synaptic Transmission and Long-term Potentiation at the Mossy Fiber Synapse of the Hippocampus
Author: Marc Gabriel WeisskopfPublisher:
ISBN:
Category : Hippocampus (Brain)
Languages : en
Pages : 414
Book Description
Disinhibition at Feedforward Inhibitory Synapses in Hippocampal Area CA1 Induces a Form of Long-Term Potentiation
Author: John Oliver Heal OrmondPublisher:
ISBN: 9780494676745
Category :
Languages : en
Pages : 252
Book Description
One of the central questions of neuroscience research has been how the cellular and molecular components of the brain give rise to complex behaviours. Three major breakthroughs from the past sixty years have made the study of learning and memory central to our understanding of how the brain works. First, the psychologist Donald Hebb proposed that information storage in the brain could occur through the strengthening of the connections between neurons if the strengthening were restricted to neurons that were co-active (Hebb, 1949). Second, Milner and Scoville (1957) showed that the hippocampus is required for the acquisition of new long-term memories for consciously accessible, or declarative, information. Third, Bliss and Lomo (1973) demonstrated that the synapses between neurons in the dentate gyrus of the hippocampus could indeed be potentiated in an activity-dependent manner. Long-term potentiation (LTP) of the glutamatergic synapses in area CA1, the primary output of the hippocampus, has since become the leading model of synaptic plasticity due to its dependence on NMDA receptors (NMDARs), required for spatial and temporal learning in intact animals, and its robust pathway specificity. Using whole-cell recording in hippocampal slices from adult rats, I find that the efficacy of synaptic transmission from CA3 to CA1 can in fact be enhanced without the induction of classic LTP at the glutamatergic inputs. Taking care not to directly stimulate inhibitory fibers, I show that the induction of GABAergic plasticity at feedforward inhibitory inputs in CA1 results in the reduced shunting of excitatory currents, producing a long-term increase in the amplitude of Schaffer collateral-mediated postsynaptic potentials which is dependent on NMDAR activation and is pathway specific. The sharing of these fundamental properties with classic LTP suggests the possibility of a previously unrecognized target for therapeutic intervention in disorders linked to memory deficits, as well as a potentially overlooked site of LTP expression in other areas of the brain.
Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels
Author: Publisher: Academic Press
ISBN: 0128026316
Category : Science
Languages : en
Pages : 379
Book Description
This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field. - Presents a comprehensive overview of the latest research into GIRK potassium channels - Serves as a perfect starting point for researchers and practitioners entering the field - Expands the literature and field of neurobiology