Author: Dr. Shmmon Ahmad Publisher: Kindle Direct Publishing ISBN: Category : Medical Languages : en Pages : 56
Book Description
After many years of industrial experience in the Pharmaceutical Industry, serving as a Quality Assurance Officer and Production Officer, I felt compelled to share my insights. Throughout my career in various manufacturing companies, I witnessed a series of mishaps, accidents, injuries, near misses, fires, and other incidents that underscored a critical issue. It became evident that even seasoned safety professionals often lacked a comprehensive understanding of the techniques, terminology, procedures, and systems essential for assessing, measuring, and applying the necessary tools to achieve the desired safety performance. My journey eventually led me to the role of an educator at Glocal University Saharanpur, where I taught Quality Assurance subjects. In my opinion, these subjects require continuous evaluation and updating to remain relevant in an ever-evolving industrial landscape. I firmly believe that certain topics hold paramount importance, particularly for safety professionals and management personnel responsible for safety management within their organizations. This book delves into topics such as management responsibility, attitudinal problems, behaviour, safety thinking, motivation for creating a safety culture, and communication challenges. These subjects are approached from a practical standpoint, making them readily applicable to day-to-day safety administration. While extensive information and literature exist on motivation and communication, their specific applications in the realm of occupational safety and loss prevention are relatively scarce. I aspire to offer this book as a valuable resource to safety professionals, safety advisors and representatives, and industry line managers to improving plant facility design, training for operation and maintenance staff, and the development of safe operating procedures. Its purpose is to unravel what has gone wrong in the past and provide guidance on preventing similar incidents in the future. Regrettably, history has shown that many incidents tend to recur after a few months, often due to people moving on and lessons being forgotten. Among the various teaching methods, experiential learning has proven the most effective, as it helps retain subject matter for an extended period. Should you come across an incident described in this book that appears to have taken place in your plant, please be aware that certain details may have been altered. This alteration is intended to make it challenging for readers to pinpoint the exact location of the incident or to simplify complex narratives without compromising the core message. In some cases, the incident may not have occurred in your plant at all; it may have taken place in a different facility facing similar circumstances."
Author: T.S.S. Dikshith Publisher: CRC Press ISBN: 1420080520 Category : Science Languages : en Pages : 310
Book Description
Occupational workers frequently use, store, and dispose of toxic chemicals without knowing the possible consequences, both for the workplace and the environment. Improper use or misuse of chemical substances can result in health disorders, fatalities, or chemical disasters. Safe Use of Chemicals: A Practical Guide presents quick and comprehensive i
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309392209 Category : Science Languages : en Pages : 117
Book Description
The U.S. Department of State charged the Academies with the task of producing a protocol for development of standard operating procedures (SOPs) that would serve as a complement to the Chemical Laboratory Safety and Security: A Guide to Prudent Chemical Management and be included with the other materials in the 2010 toolkit. To accomplish this task, a committee with experience and knowledge in good chemical safety and security practices in academic and industrial laboratories with awareness of international standards and regulations was formed. The hope is that this toolkit expansion product will enhance the use of the previous reference book and the accompanying toolkit, especially in developing countries where safety resources are scarce and experience of operators and end-users may be limited.
Author: Mary T. am Ende Publisher: John Wiley & Sons ISBN: 111928550X Category : Technology & Engineering Languages : en Pages : 1435
Book Description
A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.
Author: CCPS (Center for Chemical Process Safety) Publisher: John Wiley & Sons ISBN: 111820963X Category : Technology & Engineering Languages : en Pages : 761
Book Description
Guidelines for Risk Based Process Safety provides guidelines for industries that manufacture, consume, or handle chemicals, by focusing on new ways to design, correct, or improve process safety management practices. This new framework for thinking about process safety builds upon the original process safety management ideas published in the early 1990s, integrates industry lessons learned over the intervening years, utilizes applicable "total quality" principles (i.e., plan, do, check, act), and organizes it in a way that will be useful to all organizations - even those with relatively lower hazard activities - throughout the life-cycle of a company.
Author: David J. am Ende Publisher: John Wiley & Sons ISBN: 1119285860 Category : Technology & Engineering Languages : en Pages : 1172
Book Description
A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying Presents updated and expanded example calculations Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industryf ocuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.
Author: Michael K. Pugsley Publisher: Springer ISBN: 366246943X Category : Medical Languages : en Pages : 477
Book Description
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Author: David J. am Ende Publisher: John Wiley & Sons ISBN: 1118088107 Category : Technology & Engineering Languages : en Pages : 1431
Book Description
This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.
Author: Francis Stoessel Publisher: John Wiley & Sons ISBN: 3527339213 Category : Science Languages : en Pages : 581
Book Description
Vollständig überarbeitete,aktualisierte 2. Auflage mit fünf neuen Kapiteln und den aktuellen IUPAC-Normen. Beschäftigt sich mit thermischen Risiken in der chemischen Prozessindustrie. Jedes Kapitel beginnt mit einer Fallstudie und den aus Zwischenfällen gewonnen Erkenntnissen.
Author: CCPS (Center for Chemical Process Safety) Publisher: John Wiley & Sons ISBN: 0470935413 Category : Technology & Engineering Languages : en Pages : 784
Book Description
Chemical process quantitative risk analysis (CPQRA) as applied to the CPI was first fully described in the first edition of this CCPS Guidelines book. This second edition is packed with information reflecting advances in this evolving methodology, and includes worked examples on a CD-ROM. CPQRA is used to identify incident scenarios and evaluate their risk by defining the probability of failure, the various consequences and the potential impact of those consequences. It is an invaluable methodology to evaluate these when qualitative analysis cannot provide adequate understanding and when more information is needed for risk management. This technique provides a means to evaluate acute hazards and alternative risk reduction strategies, and identify areas for cost-effective risk reduction. There are no simple answers when complex issues are concerned, but CPQRA2 offers a cogent, well-illustrated guide to applying these risk-analysis techniques, particularly to risk control studies. Special Details: Includes CD-ROM with example problems worked using Excel and Quattro Pro. For use with Windows 95, 98, and NT.
Author: Dr. Shmmon Ahmad
Author: T.S.S. Dikshith
Author: National Academies of Sciences, Engineering, and Medicine
Author: Mary T. am Ende
Author: CCPS (Center for Chemical Process Safety)
Author: David J. am Ende
Author: Michael K. Pugsley
Author: David J. am Ende
Author: Francis Stoessel
Author: CCPS (Center for Chemical Process Safety)