A Genomic View of Alternative Splicing PDF Download

Author: Yi Xing
Publisher:
ISBN:
Category :
Languages : en
Pages : 160

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Author: Barmak Modrek
Publisher:
ISBN:
Category :
Languages : en
Pages : 150

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Author: Benjamin J. Blencowe
Publisher: Springer Science & Business Media
ISBN: 9780387773735
Category : Medical
Languages : en
Pages : 260

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Book Description
Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.

Author:
Publisher: Academic Press
ISBN: 9780128011058
Category : Science
Languages : en
Pages : 0

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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume, concentrates on the brain transcriptome.

Author:
Publisher: Academic Press
ISBN: 0128024887
Category : Science
Languages : en
Pages : 412

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Book Description
Methods in Enzymology: Visualizing RNA Dynamics in the Cell continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods visualizing RNA dynamics in the cell, and includes sections on such topics as identification of RNA cis-regulatory sequences, IRAS, IMAGEtags, MERFISH, plant RNA labeling using MS2, and visualization of 5S dynamics in live cells using photostable corn probe. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in visualizing RNA dynamics in the cell Contains sections on such topics as identification of RNA cis-regulatory sequences, IRAS, IMAGEtags, MERFISH, plant RNA labeling using MS2 and visualization of 5S dynamics in live cells using photostable corn probe

Author: Philippe Jeanteur
Publisher: Springer Science & Business Media
ISBN: 3540344497
Category : Science
Languages : en
Pages : 265

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Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.

Author: Jan Barciszewski
Publisher: Springer Science & Business Media
ISBN: 9401144850
Category : Science
Languages : en
Pages : 373

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Book Description
RNA Biochemistry and Biotechnology describes various aspects of nucleic acid and protein structure, mainly RNA structure and proteins, interacting with specific RNA species. Papers deal with DNA protein interactions, telomerase, aminoacyl-tRNA synthetases, elongation factor Tu, DNA repair, RNA structure, NMR technology, RNA aptamer interaction of biological macromolecules with metal ions. Two papers deal with theoretical aspects of RNA structure production and computer modelling. Many papers describe the possibility of commercial application of RNA biotechnology. One article discusses the impact of direct democracy on basic science supporting biotechnology. Readership: Advanced graduate students, Ph.D. students and young scientists as well as specialists in the field.

Author: Rong Kong
Publisher:
ISBN:
Category :
Languages : en
Pages : 74

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The goals of this thesis work were to study two special alternative splicing events: exon scrambling at the RNA splicing level and mutually exclusive alternative splicing (MEAS) by computational and experimental methods. Chapter 1 presents work on the study of exon scrambling, in which exons are spliced at canonical splice sites but joined together in an order different from that predicated by the genomic sequence. The public expressed sequence tag (EST) database was searched for transcripts containing scrambled exons. Stringent criteria were used to exclude genome annotation or assembly artifacts. This search identified 172 human ESTs representing 90 exon scrambling events, which derive from 85 different human genes. In several cases, the scrambled transcripts were validated using an RT-PCR-sequencing protocol, confirming the reproducibility of these unusual events. Exon scrambling of transcripts from the GLI3 gene, which encodes a transcription factor involved in hedgehog signaling, was also conserved in mouse. Specific gene features, including the presence of long flanking introns were found to be associated with exon scrambling. Chapter 2 deals with mutually exclusive alternative splicing (MEAS), in which only one of a set of two or more exons in a gene is included in the final transcript. A database with 101 human genes and 25 mouse genes containing mutually exclusive exons (MXE) has been established with GENOA annotation software. Specific sequence features were analyzed. A genome-wide search for a special "tandem MEAS" events was undertaken and 10 such human genes were identified. A fluorescence reporting system was built to study intronic cis-elements regulating MEAS.

Author: Philippe Jeanteur
Publisher: Springer Science & Business Media
ISBN: 9783540438335
Category : Science
Languages : en
Pages : 272

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The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.

Author: Rosanna Asselta
Publisher: Frontiers Media SA
ISBN: 2889662357
Category : Science
Languages : en
Pages : 197

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.