A Genetic and Molecular Analysis of Interactions Between the Drosophila Melanogaster Neurogenic Genes Delta and Notch PDF Download

Author: Scott Brockwell Shepard
Publisher:
ISBN:
Category :
Languages : en
Pages : 380

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Author: Tilman Borggrefe
Publisher: Springer
ISBN: 3319895125
Category : Science
Languages : en
Pages : 417

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Book Description
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

Author:
Publisher: Academic Press
ISBN: 0080579213
Category : Science
Languages : en
Pages : 357

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Insect physiology is currently undergoing a revolution with the increased application of molecular biological techniques to investigate the molecular mechanisms underlying the physiological responses to insect cells. Advances in Insect Physiology has instituted a commitment to the publication of high quality reviews on molecular biology and molecular genetics in areas where they provide an increased understanding of physiological processes in insects. Volume 25 contains increased coverage on the molecular biology of insect physiology.

Author: Michael William Leviten
Publisher:
ISBN:
Category :
Languages : en
Pages : 408

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Author: Pamela Jaai Kooh
Publisher:
ISBN:
Category :
Languages : en
Pages : 388

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Author: Marty Shankland
Publisher: Academic Press
ISBN: 0323141544
Category : Science
Languages : en
Pages : 559

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Determinants of Neuronal Identity brings together studies of a wide range of vertebrate and invertebrate organisms that highlight the determinants of neuronal identity. Emphasis of this book is on how neurons are generated; how their developmental identities are specified; and to what degree those identities can be subsequently modified to meet the changing needs of the organism. This book also considers various techniques used in the analysis of different organisms. This volume is comprised of 15 chapters; the first of which introduces the reader to the specification of neuronal identity in Caenorhabditis elegans. The discussion then turns to neurogenesis and segmental homology in the leech, as well as intrinsic and extrinsic factors influencing the development of Retzius neurons in the leech nervous system. Drosophila is discussed next, with particular reference to neuronal diversity in the embryonic central nervous system, cell choice and patterning in the retina, and development of the peripheral nervous system. Other chapters explore endocrine influences on the postembryonic fates of neurons during insect metamorphosis; neuron determination in the nervous system of Hydra and in the mammalian cerebral cortex; and segregation of cell lineage in the vertebrate neural crest. This book will help scientists and active researchers in synthesizing a conceptual framework for further studies of neuronal specification.

Author: Anne Grete Bang
Publisher:
ISBN:
Category :
Languages : en
Pages : 262

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Author: John Smith Dexter
Publisher:
ISBN:
Category : Animals
Languages : en
Pages : 58

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Author: Helen Sink
Publisher: Springer Science & Business Media
ISBN: 9780387300535
Category : Science
Languages : en
Pages : 224

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Book Description
The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.

Author: Paul Wassarman
Publisher: Elsevier
ISBN: 0080876781
Category : Science
Languages : en
Pages : 209

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Book Description
Volume 3 of Advances in Developmental Biology and Biochemistry consists of five chapters that review specific aspects of mammalian, fly, and ascidian development. In Chapter 1, J. Campos-Ortega discusses mechanisms of neurogenesis in Drosophila, with special attention given to the process of separation of epidermal and neural progenitor cells. In Chapter 2, D. Rappolee and Z. Werb discuss the role of growth factors in early mammalian embryos and compare genes used in mouse with those used in Xenopus and chick. In Chapter 3, E. Linney and A.-S. LaMantia discuss the range of malformations resulting from retinoid teratogenesis, the molecular biology of retinoids, the use of transgenic mice to study retinoid signaling, and differentiation of the CNS in the context of retinoid signaling. In Chapter 4, E. Gavis and R. Lehmann discuss pathways and components involved in RNA localization and targeting in Drosophila oocytes. In Chapter 5, W. Jeffery discusses the use of actin as a tissue-specific marker in studies of ascidian development and evolution