A Genetic and Molecular Analysis of Interactions Between the Drosophila Melanogaster Neurogenic Genes Delta and Notch PDF Download

Author: Scott Brockwell Shepard
Publisher:
ISBN:
Category :
Languages : en
Pages : 380

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Author: Pamela Jaai Kooh
Publisher:
ISBN:
Category :
Languages : en
Pages : 388

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Author: Nicholas James Rudzik
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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The 'neuralized' gene of 'Drosophila melanogaster' is thought to be a member of the neurogenic signalling pathway involved in the development of the embryonic and adult nervous systems. Overexpressing 'neuralized' during development causes dominant phenotypes in the eye, notum and wing of adults. These phenotypes include the production of extra and misplaced bristles in the eye, an increase in the number of notal microchaetae and decrease in macrochaetae, and deletion of portions of wing veins. These dominant phenotypes were used to screen a deficiency kit for modifiers of 'neuralized.' The screen identified deficiencies which uncovered members of both the neurogenic and the EGFR signalling pathways. This interaction was confirmed by directly testing alleles of genes in both pathways for the ability to modify the 'neuralized' overexpression phenotype. It appears that 'neuralized' could play a role in both of these pathways. Biochemical tools to test these interactions have been produced.

Author: Leslie Ann Silver
Publisher:
ISBN:
Category :
Languages : en
Pages : 134

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Author: Tilman Borggrefe
Publisher: Springer
ISBN: 3319895125
Category : Science
Languages : en
Pages : 417

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This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

Author: Craig Allen Lampitt Riedl
Publisher:
ISBN: 9780494399873
Category :
Languages : en
Pages : 326

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A major challenge for modern Biology involves the elucidation of the genetic and molecular mechanisms that underlie natural variation in behavioural phenotypes. In the fruit fly, Drosophila melanogaster, many genes that influence behaviours have been identified, primarily as a result of their mutant effects. However, the contributions of variation in these genes to naturally maintained behavioural variation is often unknown. The identification of genetic variation effecting naturally maintained behavioural variation will provide insight for therapeutic interventions. By resolving and quantifying the plasticity or flexibility present and maintained in the molecular cascades that regulate behavioural responses in natural populations, researchers will identify therapeutic limits within which it may be possible to manipulate the systems while potentially minimizing undesirable side effects. Toward enhancing the understanding of the genetic bases of natural behavioural variation, this thesis presents research on three different phenotypes, each of which have been previously described to different degrees. The first study involves an investigation meant to further resolve the molecular mechanism by which allelic variation in the for gene effects differences in foraging behaviours. The second study presents efforts to identify the genetic basis for variation in pupation position, a well-studied behaviour with known fitness consequences, and presents an initial description of associated variation in wandering behaviours. The third study investigates pupation behaviour from a more physiological perspective. In this study it was observed that larvae selected for high NaCl tolerance, which may have altered osmoregulatory abilities, pupate significantly farther from their growth media than do wild-type larvae. As a result, an effort was made to map the genetic factors effecting natural variation in NaCl tolerance. Taken as a whole, this work has the potential for extending the mechanistic understanding of complex interactions between genetic and environmental effects and the resultant behavioural responses.

Author:
Publisher: Academic Press
ISBN: 0080579213
Category : Science
Languages : en
Pages : 357

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Insect physiology is currently undergoing a revolution with the increased application of molecular biological techniques to investigate the molecular mechanisms underlying the physiological responses to insect cells. Advances in Insect Physiology has instituted a commitment to the publication of high quality reviews on molecular biology and molecular genetics in areas where they provide an increased understanding of physiological processes in insects. Volume 25 contains increased coverage on the molecular biology of insect physiology.

Author: Marty Shankland
Publisher: Academic Press
ISBN: 0323141544
Category : Science
Languages : en
Pages : 559

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Determinants of Neuronal Identity brings together studies of a wide range of vertebrate and invertebrate organisms that highlight the determinants of neuronal identity. Emphasis of this book is on how neurons are generated; how their developmental identities are specified; and to what degree those identities can be subsequently modified to meet the changing needs of the organism. This book also considers various techniques used in the analysis of different organisms. This volume is comprised of 15 chapters; the first of which introduces the reader to the specification of neuronal identity in Caenorhabditis elegans. The discussion then turns to neurogenesis and segmental homology in the leech, as well as intrinsic and extrinsic factors influencing the development of Retzius neurons in the leech nervous system. Drosophila is discussed next, with particular reference to neuronal diversity in the embryonic central nervous system, cell choice and patterning in the retina, and development of the peripheral nervous system. Other chapters explore endocrine influences on the postembryonic fates of neurons during insect metamorphosis; neuron determination in the nervous system of Hydra and in the mammalian cerebral cortex; and segregation of cell lineage in the vertebrate neural crest. This book will help scientists and active researchers in synthesizing a conceptual framework for further studies of neuronal specification.

Author: Helen Sink
Publisher: Springer Science & Business Media
ISBN: 9780387300535
Category : Science
Languages : en
Pages : 224

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The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.

Author: Michael William Leviten
Publisher:
ISBN:
Category :
Languages : en
Pages : 408

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